2-Chloro-5-fluoronicotinamide CAS 75302-64-6
| CAS No. | 75302-64-6 |
| Molecular Formula | C6H4ClFN2O |
| Molecular Weight | 174.56 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Chloro-5-fluoronicotinamide (CAS 75302-64-6), molecular formula C6H4ClFN2O and molecular weight 174.56 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, 2-Chloro-5-fluoronicotinamide (C6H4ClFN2O) contains an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 174.56 g/mol, it falls into the medium-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClFN2O |
| Molecular Weight | 174.56 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 2-Chloro-3-fluorobenzoic Acid (CAS 102940-86-3)
- 2-Chloro-5-fluoro-4-hydroxybenzaldehyde (CAS 1036383-27-3)
- 2-Chloro-6-fluoro-3-hydroxybenzaldehyde (CAS 1083103-41-6)
- 3-Chloro-6-fluoro-2-hydroxybenzaldehyde (CAS 1185112-08-6)
- 4-Chloro-5-fluoro-2-hydroxybenzaldehyde (CAS 1205551-36-5)
- 2-Chloro-3-fluoro-6-hydroxybenzaldehyde (CAS 1263378-00-2)
- 1-(6-Chloro-5-fluoro-4-pyrimidinyl)ethanone (CAS 1289559-80-3)
- 2-chloro-3-fluoropyridine-4-carboxamide (CAS 1378654-14-8)
Recommended Standards
- 2-Chloro-5-fluorobenzoic Acid (CAS 2252-50-8)
- 2-Chloro-6-fluoro-4-hydroxybenzaldehyde (CAS 917827-97-5)
- 1-(2-Chloro-5-fluoropyrimidin-4-yl)ethan-1-one (CAS 736991-76-7)
- 2-Chloro-6-fluorobenzoic acid (CAS 434-75-3)
- 1-Methyl-3-[(prop-2-en-1-yl)amino]pyrrolidin-2-one (CAS 1343805-37-7)
- 3-Azabicyclo[3.3.0]octane Hydrochloride (CAS 112626-50-3)
- CAS 2456348-62-0 (CAS 2456348-62-0)
- 4-((2-Methylpiperidin-1-yl)sulfonyl)-N-(5-(pyridin-4-yl)-1,3,4-oxadiazol-2-yl)benzamide (CAS 862824-97-3)
- 2-aldehydethiazole (CAS 10200-59-6)
- Methyl 3,4-dihydro-6-hydroxy-2H-1-benzopyran-3-carboxylate (CAS 1785318-81-1)
- 9-Methoxy-2,2-dimethyl-2,6-dihydro-5H-pyrano[3,2-c]quinolin-5-one (CAS 52617-31-9)
- 3-Amino-1-methyl-4-(4-(trifluoromethyl)phenyl)azetidin-2-one (CAS 1291488-85-1)
- N,N-Dimethyl-1H-benzo[d]imidazol-6-amine (CAS 1262887-26-2)
- Tirzepatide Impurity 33 (CAS CATO-C4X-324033)
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