6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline CAS 75414-00-5
| CAS No. | 75414-00-5 |
| Molecular Formula | C10H16F3N |
| Molecular Weight | 207.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline (CAS 75414-00-5) is a high-purity analytical reference standard with the molecular formula C10H16F3N and a molecular weight of 207.24 g/mol.
6-(trifluoromethyl)-1,2,3,4-tetrahydroquinoline (C10H16F3N) contains a nitrile group, fluorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H16F3N |
| Molecular Weight | 207.24 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related trifluoromethyl Standards
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- (4-(Trifluoromethyl)bicyclo[2.2.2]Octan-1-yl)methanamine (CAS 802029-43-2)
- 2-(Trifluoromethyl)quinoline 2-Trifluoromethyl-quinoline 347-42-2 A25656 (CAS 347-42-2)
- 5-Methyl-2-((trifluoromethyl)thio)aniline (CAS 1154963-60-6)
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Recommended Standards
- 5-Fluoro-3H-spiro[benzofuran-2,4'-piperidine] (CAS 644967-86-2)
- 6-Fluorospiro[chroman-2,1'-cyclobutan]-4-amine (CAS 934554-58-2)
- 5-Fluoro-2H-spiro[benzofuran-3,4'-piperidine] (CAS 785752-65-0)
- DL-Tryptophan-2,3,3-d3 (CAS 340257-61-6)
- (3S,5R)-3-(Boc-amino)-5-Methylpiperidine (CAS 1203651-07-3)
- tert-Butyl (7-bromo-2-oxo-1,2-dihydroquinazolin-4-yl)carbamate (CAS 2639439-52-2)
- 9-Methoxy-6-phenyl-8H-[1,3]dioxolo[4,5-g]chromen-8-one (CAS 119120-32-0)
- 2-(2-Chloroethoxy)-2-methyl-propane (CAS 17229-11-7)
- 2-(2,4-Dimethoxyphenyl)propan-2-ol (CAS 96826-27-6)
- 5-methyl-7H-pyrrolo[2,3-d]pyrimidin-2-amine (CAS 1483583-54-5)
- 2-Amino-1-((S)-2-(((cyclopropylmethyl)amino)methyl)piperidin-1-yl)propan-1-one (CAS 1354032-99-7)
- (2-(tert-Butyl)-4-cyclopropoxyphenyl)methanamine (CAS 1243357-21-2)
- n-(1-(Furan-2-yl)ethyl)-4-methylpyridin-3-amine (CAS 1344055-09-9)
- Tirzepatide Impurity 45 (CAS CATO-C4X-324045)
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