Regorafenib CAS 755037-03-7
| CAS No. | 755037-03-7 |
| Molecular Formula | C21H15ClF4N4O3 |
| Molecular Weight | 482.82 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Regorafenib (CAS 755037-03-7) is a high-purity analytical reference standard with the molecular formula C21H15ClF4N4O3 and a molecular weight of 482.82 g/mol.
The molecular framework of Regorafenib (C21H15ClF4N4O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C21H15ClF4N4O3 |
| Molecular Weight | 482.82 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 14.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Regorafenib Standards
- Regorafenib Impurity 52 (CAS CATO-C4X-104752)
- Regorafenib Impurity 7 (CAS CATO-C4X-10477)
- Regorafenib Impurity 14 (CAS 835621-12-0)
- Regorafenib D3 (CAS 1255386-16-3)
- Regorafenib-13C-D3 (CAS 2126178-55-8)
- Regorafenib-13C-d3 (CAS 755037-03-7 (Unlabeled))
- Regorafenib Impurity 75 (CAS CATO-C4X-104775)
- Regorafenib Impurity 4 (CAS 1187945-05-6)
Recommended Standards
- Methyl 30-hydroxytriacontanoate (CAS 79162-70-2)
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- (γR)- 3,4-Bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-γ-hydroxybenzenepentanoic Acid Ethyl Ester (CAS 1235828-36-0)
- (E)-[(6-{[(4-chlorophenyl)methyl]sulfanyl}imidazo[2,1-b][1,3]thiazol-5-yl)methylidene][(2,4-dichlorophenyl)methoxy]amine (CAS 338976-36-6)
- N-(3-(trifluoromethyl)phenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine (CAS 102389-25-3)
- (4-Chloro-2-fluorophenyl)methanethiol (CAS 886498-25-5)
- 4,5-Dichloro-6-iodo-1-(triisopropylsilyl)-1H-pyrrolo[2,3-b]pyridine (CAS 1346447-26-4)
- 4-Amino-N-[4-(thiophen-2-yl)pyrimidin-2-yl]benzene-1-sulfonamide (CAS 865657-84-7)
- Methyl Caprate-d (CAS 90363-39-6)
- methyl 3-carbamothioylbenzoate (CAS 106748-27-0)
- Sarpogrelate Impurity 31 (CAS 167145-28-0)
- 2-(Ethylamino)ethanethioamide (CAS 1225816-15-8)
- 1-(4-Fluorophenoxy)propan-2-one (CAS 81580-29-2)
- Insulin Degludec Impurity 15 (CAS CATO-C4X-215715)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
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