4-(3-aminopropyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride CAS 75708-27-9
| CAS No. | 75708-27-9 |
| Molecular Formula | C11H14N2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 4-(3-aminopropyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride (C11H14N2O2HCl) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
4-(3-aminopropyl)-3,4-dihydro-2H-1,4-benzoxazin-3-one hydrochloride (CAS 75708-27-9), molecular formula C11H14N2O2HCl and molecular weight 242.70 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H14N2O2 HCl |
| Molecular Weight | 242.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related aminopropyl Standards
- Benzyl 2-(3-aminopropyl)piperidine-1-carboxylate (CAS 1000561-64-7)
- [1-(3-Aminopropyl)piperidin-3-yl]methanol (CAS 100708-30-3)
- 4-(3-Aminopropyl)benzenesulfonamide (CAS 10079-78-4)
- n-(3-Aminopropyl)-3-bromobenzamide (CAS 1016507-95-1)
- 2-[2-(1-aminopropyl)phenoxy]-n-methylacetamide (CAS 1016521-84-8)
- N-(3-aminopropyl)-2-iodobenzamide (CAS 1016532-22-1)
- 5-((3-Aminopropyl)amino)thieno[3,2-b]pyridin-7(4H)-one dihydrochloride (CAS 1016552-68-3)
- 5-((3-Aminopropyl)amino)thieno[3,2-b]pyridin-7(4H)-one (CAS 1016566-94-1)
Recommended Standards
- 5-Phenylhexahydroindolizine-3,7-dione (CAS 847049-62-1)
- (<I>S</I>,<I>R</I>,<I>S</I>)-AHPC hydrochloride (CAS 1448189-80-7)
- 2,5-Dibromo-1,8-naphthyridine (CAS 1260657-29-1)
- (Perfluorohexyl)benzene (CAS 65440-93-9)
- 5-{[4-(difluoromethoxy)-3-methoxyphenyl]methylidene}-1,3-thiazolidine-2,4-dione (CAS 894259-20-2)
- N-[2-Chloro-2-(2-naphthyl)ethyl]-2,6-difluorobenzenecarboxamide (CAS 339014-46-9)
- N-(2-(thiazol-2-yl)propan-2-yl)thietan-3-amine (CAS 1862569-33-2)
- Methyl 4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate (CAS 121582-53-4)
- H-Phe-Lys(Z)-OH (CAS 68798-53-8)
- Liraglutide Impurity 17 TFA Salt (CAS CATO-C4X-199217)
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