2-Chloro-1-[4-(2-phenoxyethyl)piperazin-1-yl]ethan-1-one hydrochloride CAS 76087-80-4
| CAS No. | 76087-80-4 |
| Molecular Formula | C14H19ClN2O2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-Chloro-1-[4-(2-phenoxyethyl)piperazin-1-yl]ethan-1-one hydrochloride (CAS 76087-80-4) is a high-purity analytical reference standard with the molecular formula C14H19ClN2O2HCl and a molecular weight of 319.23 g/mol.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution, 2-Chloro-1-[4-(2-phenoxyethyl)piperazin-1-yl]ethan-1-one hydrochloride is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 319.23 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-Chloro-1-[4-(2-phenoxyethyl)piperazin-1-yl]ethan-1-one hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C14H19ClN2O2 HCl |
| Molecular Weight | 319.23 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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- 3-[(2-Chloro-4-methylsulfonyl)phenoxy]benzoic acid (CAS 1000018-31-4)
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- 2-Chloro-N-(piperidin-4-yl)-6,7-dihydro-5H-cyclopenta-[d]pyrimidin-4-amine hydrochloride (CAS 1000207-51-1)
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Recommended Standards
- 3-{[2-(1-Cyclohexen-1-yl)ethyl]amino}-N-methylpropanamide (CAS 1040691-07-3)
- Azido-PEG7-t-butyl ester (CAS 2596867-40-0)
- 2-Phenylindeno[1,2-b]pyrrol-4(1H)-one (CAS 77152-20-6)
- (S)-1-(tert-Butoxycarbonyl)-5-oxopiperazine-2-carboxylic Acid (CAS 1033713-11-9)
- Travoprost Impurity 22 (CAS CATO-C4X-192522)
- Diethyl 2-oxomalonate hydrate (CAS 133318-40-8)
- (2-((Bis(4-methoxyphenyl)phosphino)methyl)-2-methylpropane-1,3-diyl)bis(bis(4-methoxyphenyl)phosphine) (CAS 1671080-01-5)
- (S)-2-(4-Benzylmorpholin-3-yl)acetonitrile (CAS 1217855-96-3)
- (E)-5-Iodo-2-isopropyl-4-methyl-6-styrylpyrimidine (CAS 70169-98-1)
- Semaglutide Impurity 8 (CAS CATO-C4X-22268)
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