8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride CAS 762240-94-8
| CAS No. | 762240-94-8 |
| Molecular Formula | C12H11F3N4 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (CAS 762240-94-8), molecular formula C12H11F3N4HCl and molecular weight 304.70 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 8-Phenyl-3-(trifluoromethyl)-5,6,7,8-tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (C12H11F3N4HCl) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H11F3N4 HCl |
| Molecular Weight | 304.70 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 4 |
Related Phenyl Standards
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Recommended Standards
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- tert-Butyl 3-[amino(cyclopropyl)methyl]azetidine-1-carboxylate (CAS 1781803-78-8)
- Tofacitinib Impurity 149 (CAS 861612-04-6)
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- 4-(4-Bromophenyl)thiazole-2-carbaldehyde (CAS 383142-67-4)
- 2-((6-Methoxyquinolin-4-yl)methyl)quinuclidin-3-one (CAS 66113-89-1)
- Tipiracil Impurity 6 Chloride (CAS CATO-C4X-100511)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
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