Methyl 2-fluoro-3-oxo-3-phenylpropanoate CAS 76435-47-7
| CAS No. | 76435-47-7 |
| Molecular Formula | C10H9FO3 |
| Molecular Weight | 196.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Methyl 2-fluoro-3-oxo-3-phenylpropanoate (C10H9FO3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Methyl 2-fluoro-3-oxo-3-phenylpropanoate (CAS 76435-47-7), molecular formula C10H9FO3 and molecular weight 196.18 g/mol, is a CATO reference standard with documented purity and traceability.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H9FO3 |
| Molecular Weight | 196.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1978 |
| Halogen Content | F-containing |
Related Methyl Standards
- (E)-3-(4-Fluoro-3-methoxyphenyl)acrylic acid (CAS 1081765-44-7)
- 3-Fluoro-2-methoxycinnamic acid (CAS 1092460-67-7)
- N-(3-Fluoro-2-methylphenyl)-2-(hydroxyimino)acetamide (CAS 114895-95-3)
- N-(4-fluoro-2-methylphenyl)-2-(N-hydroxyimino)acetamide (CAS 1235441-78-7)
- 5-Fluoro-2-methyl-2,3-dihydrobenzofuran-7-carboxylic acid (CAS 123656-38-2)
- 3-(4-Fluoro-2-methylphenyl)-2-oxopropanoic acid (CAS 1249266-47-4)
- Methyl 2-(4-fluoro-3-methylphenyl)-2-oxoacetate (CAS 1267230-81-8)
- 7-Fluoro-6-methoxychroman-4-one (CAS 1273653-44-3)
Recommended Standards
- Methyl 2-(4-fluoro-2-methylphenyl)-2-oxoacetate (CAS 334477-07-5)
- Methyl 3-(3-Fluorophenyl)-3-oxopropanoate (CAS 260246-17-1)
- Ethyl (diethoxymethyl)phosphinate (CAS 65600-74-0)
- Methyl 3-(4-fluorophenyl)-2-oxopropanoate (CAS 99334-16-4)
- S-(4-methoxyphenyl) ethanethioate (CAS 60787-31-7)
- N-(2,4-Dimethylphenyl)-4-methyl-3-morpholinothiazol-2(3H)-imine hydrochloride (CAS 1180039-80-8)
- tert-Butyl 5-cyano-2-hydroxy-1H-indole-1-carboxylate (CAS 1881293-43-1)
- 3-(Isoquinolin-1-yl)propanoic acid (CAS 344334-31-2)
- cis-3-(benzyloxy)cyclobutanamine (CAS 206660-72-2)
- ((2R,7aS)-2-Fluorohexahydro-1H-pyrrolizin-7a-yl)methanamine (CAS 2097518-31-3)
- 4-Phenoxyisoquinoline (CAS 62215-36-5)
- 3-[(4-Ethylphenoxy)methyl]piperidine (CAS 946713-40-2)
- 5-(1,1-Dimethylethyl)-1-methyl-N-[(phenylmethoxy)carbonyl]-L-glutamate (CAS 56877-41-9)
- Semaglutide Impurity 192 (CAS CATO-C4X-2226192)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com