Potassium Clavulanate EP Impurity J HCl CAS 7677-21-6
| CAS No. | 7677-21-6 |
| Molecular Formula | C6H16N2 |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of Potassium Clavulanate EP Impurity J HCl (C6H16N2HCl) is characterized by chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a process- or degradation-related impurity, Potassium Clavulanate EP Impurity J HCl (CAS 7677-21-6, C6H16N2HCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a certified reference material (CRM), Potassium Clavulanate EP Impurity J HCl meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C6H16N2 2*HCl |
| Molecular Weight | 152.67 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | -1.0 |
| CAS Registry Year (est.) | 1959 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Potassium Standards
- Clavulanate Potassium EP Impurity M DiHCl (CAS 103526-47-2)
- Potassium Clavulanate EP Impurity K (CAS 107-45-9)
- Potassium Clavulanate EP Impurity J (CAS 110-18-9)
- Potassium Clavulanate impurity 23 (CAS 112240-59-2)
- Clavulanate EP Impurity E (CAS 1260617-10-4)
- Potassium Clavulanate EP Impurity F (CAS 1260857-16-6)
- Potassium Clavulanate impurity 25 (CAS 128173-47-7)
- Potassium Clavulanate impurity 22 (CAS 148601-26-7)
Recommended Standards
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- 1253791-09-1 3183AD C16H13N3O4 Ethyl 5-hydroxy-7-oxo-2-phenyl-7,8-dihydropyrido-[2,3-d]pyrimidine-6-carboxylate (CAS 1253791-09-1)
- CBP501 Affinity Peptide trifluoroacetate salt (CAS 1351804-17-5)
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