6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline CAS 769172-75-0
| CAS No. | 769172-75-0 |
| Molecular Formula | C20H22F3NO2 |
| Molecular Weight | 365.39 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline (CAS 769172-75-0), molecular formula C20H22F3NO2 and molecular weight 365.39 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 6,7-Dimethoxy-1-(4-(trifluoromethyl)phenethyl)-1,2,3,4-tetrahydroisoquinoline (C20H22F3NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C20H22F3NO2 |
| Molecular Weight | 365.39 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Dimethoxy Standards
- 769172-81-8 (1S)-6,7-Dimethoxy-1-{2-[4-(trifluoromethyl)phenyl]ethyl}-1,2,3,4-tetrahydroisoquinoline DTXSID00657513 (CAS 769172-81-8)
- 6,7-Dimethoxy-2-(4-phenylpiperazin-1-yl)quinazolin-4-amine (CAS 331258-43-6)
- 6,7-Dimethoxy-N-[4-(trifluoromethoxy)phenyl]quinazolin-4-amine (CAS 296234-68-9)
- 2,4-Dimethoxy-N-((2,3,4,9-tetrahydro-1H-carbazol-6-yl)methyl)benzamide (CAS 852138-22-8)
- 18,19-Dimethoxy-6-methyl-4,5,9,13-tetraazapentacyclo[11.8.0.0^{3,11}.0^{4,8}.0^{16,21}]henicosa-3(11),5,7,9,16(21),17,19-heptaen-12-one (CAS 861209-62-3)
- 2,6-Dimethoxy-N-(3-(2-phenylpropan-2-yl)isoxazol-5-yl)benzamide (CAS 82558-78-9)
- 6,7-Dimethoxy-N-(4-morpholinophenyl)quinazolin-4-amine (CAS 477855-21-3)
- N-[4-(5,6-Dimethoxy-N-phthalimidinyl)phenyl]maleimide (CAS 143503-03-1)
Recommended Standards
- 4-(4-(4-Methylpiperazin-1-yl)-3-nitrophenyl)phthalazin-1-ol (CAS 797766-21-3)
- Ethyl bis((1H-benzo[d][1,2,3]triazol-1-yl)methyl)glycinate (CAS 300678-15-3)
- Leteprinim (potassium) (CAS 192564-13-9)
- N1-(4-bromo-2,6-difluorophenyl)-2,3,3-trichloroacrylamide (CAS 646989-60-8)
- 2-(Azetidin-3-yl)-4,6-dimethylpyrimidine (CAS 1236861-92-9)
- 4-(2-Chloro-6-phenylpyrimidin-4-yl)morpholine (CAS 54994-38-6)
- (3-((1,4-Dioxa-8-azaspiro[4.5]Decan-8-yl)methyl)phenyl)(2-chloro-4-fluorophenyl)methanone (CAS 898762-11-3)
- 3-(5-Chlorothiophen-2-yl)benzoic acid (CAS 920294-01-5)
- 4-(Propan-2-ylidene)-1,2,3,4,5,6-hexahydrocyclopenta[c]pyrazole (CAS 857353-22-1)
- tert-Butyl 6-cyclopropyl-3-iodo-6,7-dihydropyrazolo[1,5-a]pyrazine-5(4H)-carboxylate (CAS 2447582-30-9)
- Asiaticoside B (CAS 125265-68-1)
- 4-(difluoromethyl)-1,3-oxazole-5-carboxylic acid (CAS 1849376-53-9)
- 1-(Methoxymethyl)cyclopent-3-ene-1-carboxylic acid (CAS 1997749-69-5)
- Custom peptides (CAS CATO-CPTD788509)
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