Everolimus Impurity 37 CAS 769905-89-7
| CAS No. | 769905-89-7 |
| Molecular Formula | C53H85NO15 |
| Molecular Weight | 976.24 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Everolimus Impurity 37 (CAS 769905-89-7, C53H85NO15) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Everolimus Impurity 37 (C53H85NO15) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C53H85NO15 |
| Molecular Weight | 976.24 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 1 |
Related Everolimus Standards
- Everolimus Impurity 46 (CAS CATO-C4X-112246)
- Everolimus Impurity 12 (CAS CATO-C4X-112212)
- Everolimus O-Ethyl Impurity (CAS 1704711-12-5)
- Everolimus-13C2,D4 (~90%)DISCONTINUED. Please see E945402. (CAS 1661009-29-5)
- Everolimus Impurity 38 (CAS CATO-C4X-112238)
- Everolimus Impurity 40 (CAS CATO-C4X-112240)
- Everolimus Impurity 48 (CAS CATO-C4X-112248)
- Everolimus Impurity 32 (CAS CATO-C4X-112232)
Recommended Standards
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