【禁售不询】Pethidine EP Impurity E CAS 77-17-8
| CAS No. | 77-17-8 |
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.31 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, 【禁售不询】Pethidine EP Impurity E (CAS 77-17-8, C14H19NO2) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Owing to a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, 【禁售不询】Pethidine EP Impurity E is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 233.31 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H19NO2 |
| Molecular Weight | 233.31 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 1 |
Related Pethidine Standards
- Pethidine EP Impurity D (CAS 28030-27-5)
- Pethidine Impurity 5 (CAS 59119-18-5)
- Pethidine Impurity 4 (CAS 92197-36-9)
- Pethidine impurity 6 (CAS CATO-C4X-22326)
- Pethidine impurity 7 (CAS CATO-C4X-22327)
- Pethidine Hydrochloride EP Impurity C (CAS CATO-C4X-22324)
- Pethidine Impurity 2 (CAS 79858-48-3)
- Pethidine Impurity 6 (CAS 6094-60-6)
Recommended Standards
- 4-(2-Ethyl-6-methylphenyl)-5-methyl-3-morpholinone (CAS 120375-14-6)
- 2-Benzyloxy-1-ethoxy-d5-pyrocatechol (CAS 117320-29-3)
- Cimbuterol (CAS 54239-39-3)
- Benzo[c]phenanthrene-1,2,3,4,5-d5 (CAS 1795011-61-8)
- Prilocaine Impurity 13 (CAS 19343-15-8)
- Tiotropium Impurity 34 (CAS 169219-67-4)
- Torasemide EP Impurity C (CAS 58155-35-4)
- 2-(Bromomethyl)-N,N-dimethyl-2-propenamide (CAS 911011-46-6)
- 2-Methyl-4-(4-methyl-1,1-dioxido-3-oxoisothiazolidin-2-yl)benzenesulfonyl chloride (CAS 927997-24-8)
- 3-(2-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)ethyl)cyclobutane-1-carboxylic acid (CAS 2353570-00-8)
- 2-CHLORO-4-BROMOBENZOIC ACID 4-Bromo-2-chlorobenzoic acid 59748-90-2 AS01793 ATTERCOP-CHM AT111793 RARECHEM AL BO 2371 (CAS 59748-90-2)
- (3-Methoxy-5-(trifluoromethyl)phenyl)methanamine (CAS 916420-96-7)
- 8-Amino-6-methyl-3,4-dihydroquinolin-2(1H)-one (CAS 1243250-09-0)
- Tirzepatide Impurity 11 TFA salt (CAS CATO-C4X-324011)
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