7-Chloro-2,4-dimethyl-[1,8]naphthyridine CAS 77223-21-3
| CAS No. | 77223-21-3 |
| Molecular Formula | C10H9ClN2 |
| Molecular Weight | 192.64 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
7-Chloro-2,4-dimethyl-[1,8]naphthyridine (CAS 77223-21-3), molecular formula C10H9ClN2 and molecular weight 192.64 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 7-Chloro-2,4-dimethyl-[1,8]naphthyridine (C10H9ClN2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 7-Chloro-2,4-dimethyl-[1,8]naphthyridine meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C10H9ClN2 |
| Molecular Weight | 192.64 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
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Recommended Standards
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- 2-Chloro-5-ethyl-5H-pyrrolo[3,2-d]pyrimidine (CAS 1415346-17-6)
- Glasdegib maleate, >98% (HPLC) (CAS 2030410-25-2)
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- (S)-1-(tert-Butoxycarbonyl)-4-(5-(trifluoromethyl)-pyridin-2-yl)piperazine-2-carboxylic acid 1786754-77-5 (CAS 1786754-77-5)
- 2,3,4,9-Tetrahydro-1H-carbazol-1-ol (CAS 1592-62-7)
- 6-(tert-Butyl)-4-cyclopropoxy-N-methylpyridin-3-amine (CAS 1243352-78-4)
- Allo-D-Ile27-Tirzepatide (CAS CATO-CPTD788961)
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