Methyl 3-chloro-2-fluoro-5-(trifluoromethyl)benzoate CAS 773874-03-6
| CAS No. | 773874-03-6 |
| Molecular Formula | C9H5ClF4O2 |
| Molecular Weight | 256.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), Methyl 3-chloro-2-fluoro-5-(trifluoromethyl)benzoate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Methyl 3-chloro-2-fluoro-5-(trifluoromethyl)benzoate (CAS 773874-03-6), molecular formula C9H5ClF4O2 and molecular weight 256.58 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system, Methyl 3-chloro-2-fluoro-5-(trifluoromethyl)benzoate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 256.58 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C9H5ClF4O2 |
| Molecular Weight | 256.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
Related Methyl Standards
- 2-(3-Chloro-2-fluoro-4-(trifluoromethyl)phenyl)acetic acid (CAS 1431329-72-4)
- 2-(4-Chloro-3-fluoro-5-(trifluoromethyl)phenyl)acetic acid (CAS 1431329-73-5)
- Methyl 2-chloro-4-fluoro-3-(trifluoromethyl)benzoate (CAS 1805457-90-2)
- Methyl 6-chloro-2-fluoro-3-(trifluoromethyl)benzoate (CAS 1805458-07-4)
- Methyl 5-chloro-2-fluoro-4-(trifluoromethyl)benzoate (CAS 1805524-68-8)
- Methyl 5-chloro-4-fluoro-2-(trifluoromethyl)benzoate (CAS 1805524-74-6)
- Methyl 2-chloro-5-fluoro-3-(trifluoromethyl)benzoate (CAS 1805955-89-8)
- 2-(3-Chloro-2-fluoro-5-(trifluoromethyl)phenyl)acetic acid (CAS 261763-13-7)
Recommended Standards
- 3-Chloro-2-fluoro-6-(trifluoromethyl)phenylacetic acid (CAS 261763-14-8)
- 3-bromo-7-chlorothieno[2,3-c]pyridine (CAS 1315360-86-1)
- 3-Chloro-2-fluoro-6-(trifluoromethyl)-Benzoic Acid Methyl Ester (CAS 773873-99-7)
- 3-bromo-5-chlorothieno[2,3-c]pyridine (CAS 1326715-11-0)
- 3-Fluorophenyl 5-(1,2,3-thiadiazol-4-yl)thiophene-2-sulfonate (CAS 338400-16-1)
- 3-Amino-N,N-diethyl-4,5-dimethylbenzene-1-sulfonamide (CAS 848179-07-7)
- 1-(3-Bromopropyl)-4-(trifluoromethyl)benzene (CAS 178369-93-2)
- 4-(Cyclopropylmethyl)-1,2-dimethoxybenzene (CAS 479484-78-1)
- N-(2-Methoxybenzyl)-1-(3-methyl-1-propyl-1H-pyrazol-4-yl)methanamine hydrochloride (CAS 1856032-72-8)
- Ipragliflozin Impurity 2 (CAS CATO-C4X-18852)
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- 5-Bromo-[1,3]dioxolo[4,5-g]isoquinoline (CAS 1367810-46-5)
- 30003-72-6 insulin chain b oxidized (CAS 30003-72-6)
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