1,4-Bis(bromomethyl)-2,3,5,6-tetrafluorobenzene CAS 776-40-9
| CAS No. | 776-40-9 |
| Molecular Formula | C14H9BrF4 |
| Molecular Weight | 333.12 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1,4-Bis(bromomethyl)-2,3,5,6-tetrafluorobenzene (CAS 776-40-9), molecular formula C14H9BrF4 and molecular weight 333.12 g/mol, is a CATO reference standard with documented purity and traceability.
Owing to fluorine/bromine substitution, a polycyclic aromatic system, 1,4-Bis(bromomethyl)-2,3,5,6-tetrafluorobenzene is typically pale yellow to yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 333.12 g/mol — guide the selection of appropriate sample preparation and analytical techniques. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H9BrF4 |
| Molecular Weight | 333.12 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F/Br-containing |
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Recommended Standards
- (R)-2-Acetamido-3-(4-iodophenyl)propanoic acid (CAS 201351-59-9)
- 2-(4-Iodobenzoyl)benzonitrile (CAS 890098-79-0)
- (2R)-2-[(2-iodo-3-methylphenyl)formamido]propanoic acid (CAS 1604308-75-9)
- 2-Cyano-2-iodobenzophenone (CAS 890098-75-6)
- 3',5'-Dimethyl-[1,1'-biphenyl]-3-carbaldehyde (CAS 842140-47-0)
- 2-(Chloromethyl)-5-cyano-6-(difluoromethyl)pyridine-3-acetic acid (CAS 1806960-59-7)
- 6-Bromo-2-phenyl-1H-indole (CAS 77185-71-8)
- 2,3-Dichloro-5,6-difluorobenzoic acid (CAS 1263376-91-5)
- 1022528-34-2 ((4-Chloro-2-nitrophenyl)sulfonyl)(3-methyl(2-pyridyl))amine MFCD03839775 (CAS 1022528-34-2)
- 2,2,6,6-Tetramethyl-4-azide-piperidin-1-oxyl 4-Azido-2,2,6,6-tetramethyl-1-piperidinyloxy 4-Azido-2,2,6,6-tetramethylpiperidin-1-yloxy 63697-61-0 NSC 300606 (CAS 63697-61-0)
- 3-Cyclopropyl-1-isobutyl-1H-pyrazole-4-carbaldehyde (CAS 1006496-19-0)
- 3-Chloro-1H-indole (CAS 16863-96-0)
- 5’-Bromo-2,2,2,2’-tetrafluoroacetophenone (CAS 617706-15-7)
- Des-Asp15-Tirzepatide (CAS CATO-CPTD788958)
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