Thyroxine Impurity 1 CAS 77667-01-7
| CAS No. | 77667-01-7 |
| Molecular Formula | C15H11BrI3NO4 |
| Molecular Weight | 729.87 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Thyroxine Impurity 1 (CAS 77667-01-7), molecular formula C15H11BrI3NO4 and molecular weight 729.87 g/mol, is a CATO reference standard with documented purity and traceability.
Structurally, Thyroxine Impurity 1 (C15H11BrI3NO4) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine/iodine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 729.87 g/mol, it falls into the high-molecular-weight range. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Thyroxine Impurity 1 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C15H11BrI3NO4 |
| Molecular Weight | 729.87 g/mol |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Br/I-containing |
| Nitrogen Atoms | 1 |
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- Semaglutide Impurity 75 (CAS CATO-C4X-2226175)
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