1-(4-Fluoro-3-nitrophenyl)propan-1-one CAS 777-48-0
| CAS No. | 777-48-0 |
| Molecular Formula | C9H8FNO3 |
| Molecular Weight | 197.16 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(4-Fluoro-3-nitrophenyl)propan-1-one (CAS 777-48-0), molecular formula C9H8FNO3 and molecular weight 197.16 g/mol, is a CATO reference standard with documented purity and traceability.
1-(4-Fluoro-3-nitrophenyl)propan-1-one (C9H8FNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C9H8FNO3 |
| Molecular Weight | 197.16 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Fluoro Standards
- 1-(4-Fluoro-2-nitrophenyl)propan-2-one (CAS 1263279-70-4)
- 1-(5-Fluoro-2-nitrophenyl)propan-2-one (CAS 1266659-06-6)
- Methyl 3-fluoro-4-formamidobenzoate (CAS 1314936-23-6)
- N-(2-Fluoro-phenyl)-malonamic acid (CAS 148356-13-2)
- 1-(5-Fluoro-2-methyl-3-nitrophenyl)ethanone (CAS 176548-78-0)
- 6'-Fluoro-2'-methyl-3'-nitroacetophenone (CAS 1804495-40-6)
- 1-(4-Fluoro-2-methyl-3-nitrophenyl)ethanone (CAS 1806375-55-2)
- 1-(2-Fluoro-3-methyl-5-nitrophenyl)ethan-1-one (CAS 1806425-70-6)
Recommended Standards
- 1-(4-fluoro-2-nitrophenyl)propan-2-one (CAS 39616-99-4)
- 1-(5-Fluoro-2-nitrophenyl)propan-1-one (CAS 924648-17-9)
- 1-(2-Fluoro-5-nitrophenyl)propan-1-one (CAS 461037-07-0)
- 1-(Trifluoromethyl)isoquinoline (CAS 26053-68-9)
- n-Methoxy-n,5-dimethylthiophene-2-carboxamide (CAS 132960-12-4)
- 2-[Benzyl(ethyl)amino]nicotinic acid (CAS 1040076-82-1)
- 2-PRopoxy-4-(trifluoromethyl)phenol (CAS 866615-48-7)
- 2-(3-Bromo-2-methyl-phenylsulfanyl)-ethanol (CAS 1824063-52-6)
- N1,N3-Bis(2-chloroethyl)propane-1,3-diamine (CAS 73276-78-5)
- 1-[6-(Trifluoromethyl)pyrimidin-4-yl]piperidin-4-amine dihydrochloride (CAS 1329672-94-7)
- 7-(3-Aminopyrrolidin-1-yl)-1-cyclopropyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid hydrochloride (CAS 106797-94-8)
- Pyrazine Impurity 3 HCl (3-Methylpyridine HCl) (CAS 14401-92-4)
- Sitafloxacin impurity 54 (CAS CATO-C4X-115554)
- Tau Peptide (379-408) trifluoroacetate salt (CAS 1246357-53-8)
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