1'-Methylspiro[benzo[e][1,3]oxazine-2,4'-piperidin]-4(3H)-one CAS 77773-95-6
| CAS No. | 77773-95-6 |
| Molecular Formula | C13H16N2O2 |
| Molecular Weight | 232.28 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1'-Methylspiro[benzo[e][1,3]oxazine-2,4'-piperidin]-4(3H)-one (CAS 77773-95-6), molecular formula C13H16N2O2 and molecular weight 232.28 g/mol, is a CATO reference standard with documented purity and traceability.
1'-Methylspiro[benzo[e][1,3]oxazine-2,4'-piperidin]-4(3H)-one (C13H16N2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. It is notably hygroscopic, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1'-Methylspiro[benzo[e][1,3]oxazine-2,4'-piperidin]-4(3H)-one meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H16N2O2 |
| Molecular Weight | 232.28 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Nitrogen Atoms | 2 |
Related Methylspiro Standards
- 1-Methylspiro[benzo[d][1,3]oxazine-4,4’-piperidin]-2(1H)-one (CAS 84060-10-6)
- 6-Methylspiro[chromane-2,4'-piperidin]-4-one (CAS 753424-31-6)
- 1-Ethyl-7-methylspiro[indoline-3,3'-pyrrolidin]-2-one (CAS 744146-12-1)
- 1-Methylspiro[indoline-3,2'-pyran]-2,6'(3'H)-dione (CAS 882041-46-5)
- (5-Methylspiro[1,3-dioxane-2,2-tricyclo[3.3.1.1~3,7~]decan]-5-yl)amine (CAS 1313829-64-9)
- 1-(5-Methylspiro[indoline-3,4'-piperidin]-1-yl)ethanone (CAS 1422135-40-7)
- 4'-Methylspiro[indoline-3,2'-morpholin]-2-one (CAS 1798828-76-8)
- 1'-Methylspiro[piperidine-4,3'-pyrrolo[2,3-b]pyridin]-2'(1'H)-one (CAS 885033-69-2)
Recommended Standards
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- 2-((2-Cyanoethyl)(phenyl)amino)ethyl acetate (CAS 22031-33-0)
- 1-Methyl-2-phenyl-1H-indole-3-carbonitrile (CAS 87613-34-1)
- tert-Butyl (3-cyano-5-formylphenyl)carbamate (CAS 2438162-99-1)
- 8-Ethyl-3,4-Dihydro-2h-1-benzopyran-4-amine hydrochloride (CAS 191608-33-0)
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- 2-Bromo-4-methoxyphenyl 3-pyrrolidinylmethylether hydrochloride (CAS 1219956-82-7)
- (S)-2-Amino-N-ethyl-N-(4-fluorobenzyl)-3-methylbutanamide (CAS 1353994-63-4)
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