1-(2,2,2-Trifluoroacetyl)piperidine-4-carbonitrile CAS 77940-79-5

Purity 97%+In StockPharmaceutical Standards
CAS No.77940-79-5
Molecular FormulaC8H9F3N2O
Molecular Weight206.17 g/mol
CategoryPharmaceutical Standards / API Standards
AvailabilityIn Stock

Chemical Structure

1-(2,2,2-Trifluoroacetyl)piperidine-4-carbonitrile CAS 77940-79-5 chemical structure

Description

Compared with other compounds in its class, the molecular weight of 206.17 g/mol gives 1-(2,2,2-Trifluoroacetyl)piperidine-4-carbonitrile distinctive chromatographic separation conditions and mass-spectrometry parameter settings.

1-(2,2,2-Trifluoroacetyl)piperidine-4-carbonitrile (CAS 77940-79-5) is a high-purity analytical reference standard with the molecular formula C8H9F3N2O and a molecular weight of 206.17 g/mol.

1-(2,2,2-Trifluoroacetyl)piperidine-4-carbonitrile (C8H9F3N2O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. Halogen substitution raises its density and boiling point; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

As a certified reference material (CRM), 1-(2,2,2-Trifluoroacetyl)piperidine-4-carbonitrile meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.

Physical & Chemical Properties

Molecular FormulaC8H9F3N2O
Molecular Weight206.17 g/mol
AppearanceOff-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility)
Purity97%+
StorageStore at 2-8°C, protect from light, keep tightly closed to prevent evaporation
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityMay oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)4.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1979
Halogen ContentF-containing
Nitrogen Atoms2

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