Diethyl 2-(2-methoxyphenyl)malonate CAS 78024-74-5
| CAS No. | 78024-74-5 |
| Molecular Formula | C14H18O5 |
| Molecular Weight | 266.29 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of Diethyl 2-(2-methoxyphenyl)malonate is closely related to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
Diethyl 2-(2-methoxyphenyl)malonate (CAS 78024-74-5) is a high-purity analytical reference standard with the molecular formula C14H18O5 and a molecular weight of 266.29 g/mol.
Owing to a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system, Diethyl 2-(2-methoxyphenyl)malonate is typically off-white to pale yellow crystalline powder. Its solid-state physicochemical attributes — including a molecular weight of 266.29 g/mol — guide the selection of appropriate sample preparation and analytical techniques. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H18O5 |
| Molecular Weight | 266.29 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
Related Diethyl Standards
- Diethyl 2-(o-tolyloxy)malonate (CAS 100972-86-9)
- 1,3-Diethyl 2,2-bis(2-cyanoethyl)propanedioate (CAS 1444-05-9)
- 1,3-diethyl 2-(3-methoxyphenyl)propanedioate (CAS 50874-07-2)
- Diethyl 2-(4-Methoxyphenyl)malonate (CAS 23197-67-3)
- Diethyl 2-(benzyloxy)malonate (CAS 5778-35-8)
- Diethyl 2-(hydroxymethyl)-2-phenylmalonate (CAS 278791-10-9)
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Recommended Standards
- Clobazam EP Impurity B (CAS 22316-24-1)
- Butyl 2,4-dioxo-1,2,3,4,5,6,7,8-octahydroquinazoline-6-carboxylate (CAS 5437-56-9)
- Boc-D-Ala(3'-pyridyl)-OH (CAS 98266-33-2)
- Boc-(s)-3-amino-3-(3-pyridyl)-propionic acid (CAS 297773-45-6)
- 3,5-Dimethyl-1H-pyrazole-1-carbonyl chloride (CAS 49652-39-3)
- 4h-Benzo[e][1,2,4]triazolo[5,1-c][1,2,4]thiadiazine-7-carboxylic acid 5,5-dioxide (CAS 1311316-98-9)
- 1-(4-Cyanophenyl)-N-(2-methoxyethyl)methanesulfonamide (CAS 1041567-41-2)
- (2R,3R)-2-Amino-3-phenyl-butyric acid ethyl ester hydrochloride (CAS 2331211-84-6)
- Methyl 1-cyclopropyl-1H-benzo[d][1,2,3]triazole-5-carboxylate (CAS 887350-84-7)
- (2-Chloro-5-methylpyridin-3-yl)methanamine hydrochloride (CAS 1432754-65-8)
- Theta-Cypermethrin (CAS 71697-59-1)
- di(pyridin-3-yl)methane (CAS 78210-43-2)
- (+/-)-1-Bromo-4-(trans-2-(trifluoromethyl)cyclopropyl)benzene (CAS 900779-70-6)
- Semaglutide impurity 229 (CAS CATO-C4X-2226229)
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