5-Chloro-2-hydroxy-N-(pyridin-4-yl)benzamide CAS 783371-31-3
| CAS No. | 783371-31-3 |
| Molecular Formula | C12H9ClN2O2 |
| Molecular Weight | 248.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 5-Chloro-2-hydroxy-N-(pyridin-4-yl)benzamide.
CATO supplies 5-Chloro-2-hydroxy-N-(pyridin-4-yl)benzamide (CAS 783371-31-3), a certified reference material (molecular formula C12H9ClN2O2, MW 248.67 g/mol) for analytical method development and quality control.
Structurally, 5-Chloro-2-hydroxy-N-(pyridin-4-yl)benzamide (C12H9ClN2O2) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. The molecule exhibits a degree of unsaturation (DBE) of 9.0, corresponding to approximately 9 ring(s) or double-bond equivalent(s). With a molecular weight of 248.67 g/mol, it falls into the medium-molecular-weight range. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 5-Chloro-2-hydroxy-N-(pyridin-4-yl)benzamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H9ClN2O2 |
| Molecular Weight | 248.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloro Standards
- 4-Chloro-6,8-dimethoxyquinoline-3-carbonitrile (CAS 1017049-01-2)
- 2-Chloro-N-(2-hydroxyphenyl)nicotinamide (CAS 10189-45-4)
- 4-(6-Chloro-pyrazin-2-yl)-3-methyl-benzoic acid (CAS 1020718-71-1)
- 4-(6-Chloro-pyrazin-2-yl)-2-methyl-benzoic acid (CAS 1020718-74-4)
- Methyl 4-(2-Chloro-4-pyrimidinyl)benzoate (CAS 1026029-33-3)
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Recommended Standards
- 4-Chloro-N'-(furan-2-ylmethylene)benzohydrazide (CAS 93418-01-0)
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- 4-Chloro-6,7-dimethoxy-3-quinolinecarbonitrile (CAS 214470-55-0)
- 6-Chloro-6'-methyl-[2,3'-bipyridine]-5-carboxylic acid (CAS 65049-29-8)
- 4-Oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxylic acid (CAS 1029721-02-5)
- 7-Amino-4-ethyl-2H-1,4-benzoxazin-3(4H)-one hydrochloride (CAS 1269397-43-4)
- Sodium 2-oxo-1,2-dihydroquinolin-4-olate (CAS 4510-76-3)
- 1-(3-Methyl-1,2,4-thiadiazol-5-yl)-1,4-diazepane (CAS 1354961-32-2)
- Ritodrine impurity 5 (CAS CATO-C4X-27435)
- 1-(3-Methyl-1-benzofuran-2-yl)methanamine (CAS 3782-23-8)
- Methyl 4,4,4-Trichlorobutanoate (CAS 19376-57-9)
- 2-Amino-5-(trifluoromethyl)-3-((trimethylsilyl)ethynyl)benzonitrile (CAS 1221792-67-1)
- Piribedil Impurity N5 (CAS 1022849-90-6)
- Des-[Ser]8-Liraglutide (CAS CATO-C4X-199233)
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