2,2-Methylenebis(4-bromophenol) CAS 78563-03-8
| CAS No. | 78563-03-8 |
| Molecular Formula | C13H10Br2O2 |
| Molecular Weight | 358.03 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2,2-Methylenebis(4-bromophenol) (CAS 78563-03-8) is a high-purity analytical reference standard with the molecular formula C13H10Br2O2 and a molecular weight of 358.03 g/mol.
The molecular framework of 2,2-Methylenebis(4-bromophenol) (C13H10Br2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, bromine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C13H10Br2O2 |
| Molecular Weight | 358.03 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 8.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Br-containing |
Related Methylenebis Standards
- 4,4'-Methylenebis(3-methyl-1-phenyl-1H-pyrazol-5(4H)-one) (CAS 7149-40-8)
- 4,4′-Methylenebis(2,6-diethylphenyl isocyanate) (CAS 105442-35-1)
- 4,4'-Methylenebis(benzenesulfonyl Chloride) (CAS 3119-64-0)
- 4,4'-Methylenebis(2,6-diisopropylaniline) (CAS 19900-69-7)
- 2,2'-Methylenebis(4-ethyl-6-tert-butylphenol) (CAS 88-24-4)
- 2,2'-methylenebis(hexahydro-1H-4,7-methanoisoindole-1,3(2H)-dione) (CAS CATO-C3D-262729)
- 4,4'-Methylenebis(2-(tert-butyl)-5-methylphenol) (CAS 2872-08-4)
- 4,4-Methylenebis(2-tert-butyl-6-methylphenol) (CAS 96-65-1)
Recommended Standards
- Methyl 4-bromo-1-(bromomethyl)-2-naphthoate (CAS 1354035-49-6)
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- 2-(4-(Difluoromethyl)-6-iodo-5-nitropyridin-3-yl)acetic acid (CAS 1804863-17-9)
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- 153229-31-3 C35H44O13 Taxayunnansin A W1319 (CAS 153229-31-3)
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- (S)-1-(3,5-Dimethylpyridazin-4-yl)ethan-1-ol (CAS 2800226-86-0)
- 3,8-dibromo-1,5-naphthyridine (CAS 154015-16-4)
- Tirzepatide Impurity 49 (CAS CATO-C4X-324049)
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