N-(4-Chlorophenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide CAS 785706-83-4
| CAS No. | 785706-83-4 |
| Molecular Formula | C17H20ClN3O3 |
| Molecular Weight | 349.81 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
As a certified reference material (CRM), N-(4-Chlorophenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
N-(4-Chlorophenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (CAS 785706-83-4) is a high-purity analytical reference standard with the molecular formula C17H20ClN3O3 and a molecular weight of 349.81 g/mol.
The molecular framework of N-(4-Chlorophenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (C17H20ClN3O3) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C17H20ClN3O3 |
| Molecular Weight | 349.81 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- 8-(2-(4-Chlorophenyl)acetyl)-1,3-dimethyl-1,3,8-triazaspiro[4.5]decane-2,4-dione (CAS 1040672-75-0)
- 1-[(2-Chlorophenyl)methoxy]-2-(4-methylphenyl)-1H-imidazo[4,5-b]pyridine (CAS 339027-11-1)
- 11-(2-Chlorophenyl)-5,11,12,12a-tetrahydropyrazolo[3',4':4,5]pyrido[2,1-a]isoquinolin-8(6H)-one (CAS 339012-03-2)
- 11-(4-Chlorophenyl)-5,11,12,12a-tetrahydropyrazolo[3',4':4,5]pyrido[2,1-a]isoquinolin-8(6H)-one (CAS 339012-00-9)
- 3-(2-Chlorophenyl)-5-[(E)-2-[(3,4-dimethylphenyl)amino]ethenyl]-1,2-oxazole-4-carbonitrile (CAS 320424-87-1)
- 3-(2-Chlorophenyl)-5-methyl-N-(2-morpholinoethyl)isoxazole-4-carboxamide (CAS 349130-87-6)
- 4-[(2-chlorophenyl)methylidene]-1,2,3,4-tetrahydroacridine-9-carboxylic acid (CAS 379729-48-3)
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Recommended Standards
- n-(3-Chlorophenyl)-2-(8-methyl-2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (CAS 850301-90-5)
- Felodipine Impurity 32 (CAS CATO-C4X-109432)
- N-(3-Chloro-4-methylphenyl)-2-(2,4-dioxo-1,3-diazaspiro[4.5]decan-3-yl)acetamide (CAS 752228-01-6)
- Pefloxacin Mesilate Dihydrate EP Impurity B (CAS 70458-73-0)
- 4-Methyl-3-oxo-1h,2h,3h-pyrazolo[3,4-b]pyridine-6-carboxylic acid (CAS 862273-50-5)
- [2-(2,6-dioxo-3-piperidyl)-1,3-dioxo-isoindolin-4-yl] 2-methoxyacetate (CAS 1061604-95-2)
- 5-(4-Chlorophenyl)-3-(3-methoxyphenyl)-1-phenyl-4,5-dihydro-1H-pyrazole (CAS 338777-20-1)
- 8-Amino-3-methyl-5,6,7,8-tetrahydronaphthalen-2-ol (CAS 1337696-56-6)
- 2-(4-Pyridinyl)-4-quinolinecarboxylic acid (CAS 14228-23-0)
- tert-butyl 3-hydroxy-3-(nitromethyl)azetidine-1-carboxylate (CAS 1008526-70-2)
- 2-((4-Allyl-5-(pyridin-2-yl)-4H-1,2,4-triazol-3-yl)thio)-N-(4-chlorophenyl)acetamide (CAS 577788-98-8)
- 5-Fluoro-2-((1-methyl-1H-pyrazol-3-yl)methoxy)aniline (CAS 1260659-04-8)
- 4-Oxo-1-piperidinecarboxamide (CAS 306976-42-1)
- Semaglutide Impurity 1(OtBu-Ste-D-γGlu(OtBu)-AEEA-AEEA-OH) (CAS CATO-C4X-22261)
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