2-(Chloromethyl)-1-methylimidazole CAS 78667-04-6
| CAS No. | 78667-04-6 |
| Molecular Formula | C5H7ClN2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-(Chloromethyl)-1-methylimidazole (CAS 78667-04-6), molecular formula C5H7ClN2HCl and molecular weight 167.03 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(Chloromethyl)-1-methylimidazole (C5H7ClN2HCl) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), 2-(Chloromethyl)-1-methylimidazole meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C5H7ClN2 HCl |
| Molecular Weight | 167.03 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 2.0 |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Chloromethyl Standards
- 7-(Chloromethyl)-3-methyl-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 100003-81-4)
- 7-(Chloromethyl)-2,3-dimethyl-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 100003-82-5)
- 7-(Chloromethyl)-3-(4-chlorophenyl)-5H-thiazolo[3,2-a]pyrimidin-5-one (CAS 100003-85-8)
- chloromethyl 2-ethoxy-2-methylpropanoate (CAS 1000296-74-1)
- 5-(chloromethyl)-N-(4-methylbenzyl)-1,3,4-thiadiazole-2-carboxamide (CAS 1000932-24-0)
- 5-(Chloromethyl)-7-ethoxy-2-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyrimidine (CAS 1000932-47-7)
- 5-(chloromethyl)-N-(4-fluorobenzyl)-1,3,4-thiadiazole-2-carboxamide (CAS 1000932-60-4)
- 2-(Chloromethyl)-5,6-diphenylfuro[2,3-d]pyrimidin-4-amine (CAS 1000933-67-4)
Recommended Standards
- N-Methyl-3-(methylamino)propanamide (CAS 50836-82-3)
- Ethyl 5-cyano-1-(pyridin-4-yl)-1H-pyrazole-4-carboxylate (CAS 98476-15-4)
- rac-Lanicemine DiHCl (CAS 153200-70-5)
- 1-Propylquinazolin-4(1H)-one (CAS 3476-69-5)
- Diethyl 2-hexylmalonate (CAS 5398-10-7)
- 3-Amino-4-tert-butyl-6-(trifluoromethyl)thieno[2,3-b]pyridine-2-carboxamide (CAS 832739-30-7)
- 3-Hydroxypent-4-ynoic acid (CAS 1314901-38-6)
- (2-Fluoro-6-iodophenyl)methanamine (CAS 771579-32-9)
- m-((3-Chloro-4-(3-(2,4,6-triamino-5-pyrimidinyl)propoxy)phenyl)carbamoyl)benzenesulfonyl fluoride monoethanesulfonate (CAS 22478-95-1)
- Semaglutide Impurity 122 (CAS CATO-C4X-2226122)
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