1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One CAS 78682-09-4
| CAS No. | 78682-09-4 |
| Molecular Formula | C11H12F2O2 |
| Molecular Weight | 214.21 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One (C11H12F2O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One (CAS 78682-09-4), molecular formula C11H12F2O2 and molecular weight 214.21 g/mol, is a CATO reference standard with documented purity and traceability.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
As a certified reference material (CRM), 1-[4-(Difluoromethoxy)Phenyl]-2-Methylpropan-1-One meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C11H12F2O2 |
| Molecular Weight | 214.21 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F-containing |
Related Difluoromethoxy Standards
- 3-(4-(Difluoromethoxy)-3-methylphenyl)propanal (CAS 1803892-61-6)
- 1-(2-(Difluoromethoxy)-3-methylphenyl)propan-1-one (CAS 1803892-71-8)
- 1-(5-(Difluoromethoxy)-2-methylphenyl)propan-1-one (CAS 1803892-91-2)
- 1-(3-(Difluoromethoxy)-4-methylphenyl)propan-1-one (CAS 1804135-48-5)
- 1-(4-(Difluoromethoxy)-3-methylphenyl)propan-1-one (CAS 1805689-82-0)
- 1-(2-(Difluoromethoxy)-6-methylphenyl)propan-1-one (CAS 1805758-45-5)
- 1-(2-(Difluoromethoxy)-5-methylphenyl)propan-1-one (CAS 1806387-25-6)
- 1-(5-(Difluoromethoxy)-2-methylphenyl)propan-2-one (CAS 1806414-88-9)
Recommended Standards
- 1,2-Bis(4-fluorophenyl)ethyne (CAS 5216-31-9)
- 2-((1-(2,4-Difluorophenyl)ethyl)amino)acetamide (CAS 926252-42-8)
- (S)-5-(4,4-Difluoropiperidin-3-yl)pyridin-2(1H)-one (CAS 2767114-90-7)
- 2-[(3,3-Difluorocyclobutyl)methoxy]-4-methylpyrimidine (CAS 2200107-35-1)
- Methyl (Z)-4-hydroxy-4-mesityl-2-oxobut-3-enoate (CAS 39847-94-4)
- 2-(4-Isopropyl-phenyl)-2,6-dihydro-4H-thieno[3,4-c]pyrazol-3-ylamine (CAS 1418273-70-7)
- N-(tert-butyl)-2,6-dichloronicotinamide (CAS 1334612-24-6)
- 1-Vinylpyrimidine-2,4(1H,3H)-dione (CAS 15765-17-0)
- 4-Bromo-5-cyclopropoxy-N,N-dimethylpicolinamide (CAS 1243382-36-6)
- 1-(3-((3-Chloro-5-(trifluoromethyl)pyridin-2-yl)oxy)phenyl)-3-(2,4-dichlorobenzyl)-4-hydroxypyridin-2(1H)-one (CAS 866049-47-0)
- N-(benzo[d][1,3]dioxol-5-yl)-4-(3-phenylallyl)piperazine-1-carboxamide (CAS 1164513-65-8)
- (2S,4S)-1-((benzyloxy)carbonyl)-2-methylpiperidine-4-carboxylic acid (CAS 2381714-92-5)
- 3-Cyclopropoxy-2-iodo-5-(trifluoromethyl)pyridine (CAS 1243397-70-7)
- Peptide Impurity 12 (CAS CATO-CPTD788812)
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