2-(5-Methoxy-2,3-dihydro-1H-inden-2-yl)acetic acid CAS 78698-48-3
| CAS No. | 78698-48-3 |
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
2-(5-Methoxy-2,3-dihydro-1H-inden-2-yl)acetic acid (CAS 78698-48-3), molecular formula C12H14O3 and molecular weight 206.24 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-(5-Methoxy-2,3-dihydro-1H-inden-2-yl)acetic acid (C12H14O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 2-(5-Methoxy-2,3-dihydro-1H-inden-2-yl)acetic acid meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H14O3 |
| Molecular Weight | 206.24 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
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Recommended Standards
- 2-(4-Tert-butylphenyl)-2-oxoacetic acid (CAS 7099-90-3)
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- 2-(Allyloxy)-5-amino-N-methylbenzamide (CAS 30653-87-3)
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