1-(4-Chloro-3-fluorophenyl)ethan-1-amine CAS 787633-87-8
| CAS No. | 787633-87-8 |
| Molecular Formula | C8H9ClFN |
| Molecular Weight | 173.62 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
1-(4-Chloro-3-fluorophenyl)ethan-1-amine (CAS 787633-87-8) is a high-purity analytical reference standard with the molecular formula C8H9ClFN and a molecular weight of 173.62 g/mol.
The molecular framework of 1-(4-Chloro-3-fluorophenyl)ethan-1-amine (C8H9ClFN) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H9ClFN |
| Molecular Weight | 173.62 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F/Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 1-(2-Chloro-6-fluorophenyl)ethan-1-amine (CAS 1000878-44-3)
- (S)-1-(2-Chloro-6-fluorophenyl)ethanamine (CAS 1000922-53-1)
- (R)-1-(3-chloro-4-fluorophenyl)ethan-1-amine (CAS 1012305-33-7)
- 1-(3-Chloro-4-fluorophenyl)ethan-1-amine (CAS 1021239-38-2)
- 1-(4-Chloro-2-fluorophenyl)ethan-1-amine (CAS 1028405-72-2)
- 3-Chloro-N-ethyl-2-fluoroaniline (CAS 1040041-91-5)
- 3-Chloro-n-ethyl-4-fluoroaniline (CAS 106847-36-3)
- [(4-chloro-2-fluorophenyl)methyl](methyl)amine (CAS 1094641-62-9)
Recommended Standards
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