Tetracycline EP Impurity A CAS 79-85-6
| CAS No. | 79-85-6 |
| Molecular Formula | C22H24N2O8 |
| Molecular Weight | 444.43 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Tetracycline EP Impurity A.
CATO supplies Tetracycline EP Impurity A (CAS 79-85-6), a pharmacopoeial impurity reference standard (molecular formula C22H24N2O8, MW 444.43 g/mol) used for the identification and quantification of trace impurities in APIs.
Structurally, Tetracycline EP Impurity A (C22H24N2O8) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 12.0, corresponding to approximately 12 ring(s) or double-bond equivalent(s). With a molecular weight of 444.43 g/mol, it falls into the moderately-high-molecular-weight range. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C22H24N2O8 |
| Molecular Weight | 444.43 g/mol |
| Appearance | Pale yellow to yellow crystalline powder |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 12.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Nitrogen Atoms | 2 |
Related Tetracycline Standards
- Tetracycline EP Impurity B (CAS 6542-44-5)
- Tetracycline Impurity 8 (CAS CATO-C4X-23318)
- Tetracycline-d6 (CAS CATO-CCHM702732)
- Tetracycline-d6 (CAS 2373374-42-4)
- Tetracycline impurity 5 (CAS CATO-C4X-23315)
- Tetracycline Impurity 9 (CAS CATO-C4X-23319)
- Tetracycline EP Impurity C (CAS 1665-56-1)
- Tetracycline EP Impurity D (CAS 7518-17-4)
Recommended Standards
- Oxytetracycline EP Impurity B (CAS 60-54-8)
- Larotrectinib Impurity 22 (CAS CATO-C4X-238022)
- Doxycycline Impurity 8 (CAS CATO-C4X-19318)
- Letermovir Impurity 34 (CAS CATO-C4X-291534)
- Belumosudil Impurity 25 (CAS CATO-C4X-298825)
- Metoclopramide EP Impurity A HCl (CAS 5608-13-9(Free Base))
- Faropenem Impurity 80 (CAS CATO-C4X-128980)
- Methyl (4-dimethylaminophenyl) cyanocarbonimido-dithioate (CAS 100477-75-6)
- N-(2,3-dichlorophenyl)benzamide (CAS 10286-77-8)
- Methyl 4,5-diamino-2-bromobenzoate (CAS 1243164-72-8)
- Daidzein (CAS 486-66-8)
- 1-{2,4,5-trimethylthieno[2,3-d]pyrimidin-6-yl}ethan-1-one (CAS 941083-97-2)
- 5-Hydroxy-2-[1-methyl-1-[[benzylcarbamoyl]amino]ethyl]-6-methoxypyrimidine-4-carboxylic Acid Methyl Ester-d3 (CAS 1185032-53-4)
- (9-D-Asp) Semaglutide X Sodium salt (CAS CATO-CPTD788617)
Why CATO?
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