2-Chloro-1-[2,5-dimethyl-1-(4-methyl-1,3-thiazol-2-yl)-1h-pyrrol-3-yl]ethan-1-one CAS 790271-60-2
| CAS No. | 790271-60-2 |
| Molecular Formula | C12H13ClN2OS |
| Molecular Weight | 268.76 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-Chloro-1-[2,5-dimethyl-1-(4-methyl-1,3-thiazol-2-yl)-1h-pyrrol-3-yl]ethan-1-one.
2-Chloro-1-[2,5-dimethyl-1-(4-methyl-1,3-thiazol-2-yl)-1h-pyrrol-3-yl]ethan-1-one (CAS 790271-60-2), molecular formula C12H13ClN2OS and molecular weight 268.76 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Chloro-1-[2,5-dimethyl-1-(4-methyl-1,3-thiazol-2-yl)-1h-pyrrol-3-yl]ethan-1-one (C12H13ClN2OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H13ClN2OS |
| Molecular Weight | 268.76 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
| Sulfur Atoms | 1 |
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Recommended Standards
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- 4-(7-Methylimidazo[1,2-a]pyridin-2-yl)aniline (CAS 64730-34-3)
- N-(piperidin-4-yl)pentanamide (CAS 1016715-15-3)
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- 3,4-Difluoro-4'-(trans-4-propylcyclohexyl)biphenyl (CAS 85312-59-0)
- 3,4'-Dibromo-4-methoxy-1,1'-biphenyl (CAS 66175-40-4)
- Methyl 4-(((1-(2-fluorobenzoyl)piperidin-4-yl)methyl)carbamoyl)benzoate (CAS 1235256-10-6)
- 5-Bromo-4-fluoro-2-nitrobenzaldehyde (CAS 213382-45-7)
- (6-methyl-3-(4,8,12-trimethyltridecyl)cyclohex-3-en-1-yl)(2,6,6-trimethylcyclohexa-1,3-dien-1-yl)methanone (CAS CATO-C3D-262388)
- 2-Amino-5-phenyl-3-thiophenecarboxamide (CAS 4815-35-4)
- Insulin Degludec Impurity 11 (CAS CATO-C4X-215711)
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