Atomoxetine Impurity 8 CAS 79130-51-1
| CAS No. | 79130-51-1 |
| Molecular Formula | C11H16ClN |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Atomoxetine Impurity 8.
As a process- or degradation-related impurity, Atomoxetine Impurity 8 (CAS 79130-51-1, C11H16ClNHCl) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Atomoxetine Impurity 8 (C11H16ClNHCl) is characterized by a nitrile group, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C11H16ClN HCl |
| Molecular Weight | 234.16 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 3.0 |
| UV Absorption | UV-absorbing |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Atomoxetine Standards
- Atomoxetine Impurity 50 (CAS 1007832-68-9)
- Atomoxetine impurity 40 (CAS 1010818-92-4)
- Atomoxetine impurity 41 (CAS 1010818-92-4（free base）)
- Atomoxetine EP Impurity C (CAS 1010818-96-8)
- Atomoxetine Impurity 9 HCl (CAS 1011-59-2)
- Atomoxetine EP impurity B (CAS 105314-53-2)
- Atomoxetine impurity 01 (CAS 109306-10-7)
- Atomoxetine EP Impurity H (S-Isomer) (CAS 114133-37-8)
Recommended Standards
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