Vigabatrin EP Impurity F CAS 794466-81-2
| CAS No. | 794466-81-2 |
| Molecular Formula | C12H20N2O3 |
| Molecular Weight | 240.30 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
As a process- or degradation-related impurity, Vigabatrin EP Impurity F (CAS 794466-81-2, C12H20N2O3) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
The molecular framework of Vigabatrin EP Impurity F (C12H20N2O3) is characterized by an amino-acid-derived structure, an amide group, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C12H20N2O3 |
| Molecular Weight | 240.30 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Nitrogen Atoms | 2 |
Related Vigabatrin Standards
- Vigabatrin Impurity 6 (CAS 2512190-67-7)
- Vigabatrin Impurity 2 (CAS CATO-C4X-11962)
- Vigabatrin Impurity 7 (CAS CATO-C4X-11967)
- Vigabatrin EP Impurity E (CAS 1378466-25-1)
- Vigabatrin Impurity 13 (CAS 1824506-31-1)
- Vigabatrin Impurity 5 (CAS 2324151-81-5)
- Vigabatrin Impurity 9 (CAS 71107-20-5)
- Vigabatrin Impurity 4 (CAS 71107-19-2)
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