Siponimod impurity 27 CAS 800379-63-9
| CAS No. | 800379-63-9 |
| Molecular Formula | C25H30F3NO2 |
| Molecular Weight | 433.51 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including Siponimod impurity 27.
CATO supplies Siponimod impurity 27 (CAS 800379-63-9), a pharmacopoeial impurity reference standard (molecular formula C25H30F3NO2, MW 433.51 g/mol) used for the identification and quantification of trace impurities in APIs.
The molecular framework of Siponimod impurity 27 (C25H30F3NO2) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Siponimod impurity 27 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C25H30F3NO2 |
| Molecular Weight | 433.51 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at room temperature, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
Related Siponimod Standards
- Siponimod impurity 23 (CAS CATO-C4X-247223)
- Siponimod impurity 21 (CAS CATO-C4X-247221)
- Siponimod impurity 25 (CAS 800380-45-4)
- Siponimod Impurity 12 (CAS CATO-C4X-247212)
- Siponimod Impurity 37 (CAS CATO-C4X-247237)
- Siponimod (CAS 1230487-00-9)
- Siponimod Impurity 30 (CAS CATO-C4X-247230)
- Siponimod Impurity 34 (CAS 2768181-14-0)
Recommended Standards
- Palbociclib Impurity 20 (CAS CATO-C4X-112520)
- Biotin-PEG3-CH2COOH (CAS 1189560-96-0)
- tert-Butyl (3-(5-(2,5-difluorophenyl)-2-phenyl-2,3-dihydro-1,3,4-thiadiazol-2-yl)propyl)carbamate (CAS 913731-98-3)
- Fmoc-(2R,3S)-2-amino-3-(phenylthio)-butanoic acid (CAS 1217741-23-5)
- Peramivir Impurity 85 (CAS CATO-C4X-183385)
- Tinidazole Impurity 25 (CAS CATO-C4X-193025)
- Sitagliptin Impurity 23 (CAS CATO-C4X-114423)
- 1-Cyclopropoxy-2-fluoro-4-methylbenzene (CAS 1243481-81-3)
- 5-((4-Chlorophenoxy)methyl)thiophene-2-carboxylic acid (CAS 74556-82-4)
- (R)-3-amino-2-(3-hydroxybenzyl)propanoic acid (CAS 1190597-09-1)
- 3,5-Diethynylbenzoic acid (CAS 883106-26-1)
- 1040692-34-9 7930AC C16H27NO N-[2-(2-Isopropyl-5-methylphenoxy)ethyl]-2-butanamine (CAS 1040692-34-9)
- 5-(2,4-Dichlorophenyl)-1,3,4-thiadiazol-2-amine (CAS 28004-63-9)
- Insulin Degludec Impurity 25 (CAS CATO-C4X-215725)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com