1-Chloro-3-fluoro-3-methylbutan-2-one CAS 80212-78-8
| CAS No. | 80212-78-8 |
| Molecular Formula | C5H8ClFO |
| Molecular Weight | 138.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The occurrence of 1-Chloro-3-fluoro-3-methylbutan-2-one is closely related to a hydroxyl group, an ether linkage, fluorine/chlorine substitution in its molecular formula, which determines its behaviour during synthesis, purification, or degradation.
1-Chloro-3-fluoro-3-methylbutan-2-one (CAS 80212-78-8), molecular formula C5H8ClFO and molecular weight 138.57 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 1-Chloro-3-fluoro-3-methylbutan-2-one (C5H8ClFO) is characterized by a hydroxyl group, an ether linkage, fluorine/chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
CATO manufactures 1-Chloro-3-fluoro-3-methylbutan-2-one under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C5H8ClFO |
| Molecular Weight | 138.57 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | Stable under recommended storage conditions |
| Degree of Unsaturation (DBE) | 1.0 |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | F/Cl-containing |
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Why CATO?
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