2-(5-Chloro-2-hydroxyphenyl)isoindoline-1,3-dione CAS 80460-34-0
| CAS No. | 80460-34-0 |
| Molecular Formula | C14H8ClNO3 |
| Molecular Weight | 273.67 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including 2-(5-Chloro-2-hydroxyphenyl)isoindoline-1,3-dione.
2-(5-Chloro-2-hydroxyphenyl)isoindoline-1,3-dione (CAS 80460-34-0), molecular formula C14H8ClNO3 and molecular weight 273.67 g/mol, is a CATO reference standard with documented purity and traceability.
2-(5-Chloro-2-hydroxyphenyl)isoindoline-1,3-dione (C14H8ClNO3) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C14H8ClNO3 |
| Molecular Weight | 273.67 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1979 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Chloro Standards
- 3-Chloro-5-phenylpyrazolo[1,5-a]pyrimidine-7-carboxylic acid (CAS 1011366-25-8)
- 2-(5-Chloro-2-nitrophenyl)-1H-benzo[d]imidazole (CAS 10173-75-8)
- (6-Chloro-3-nitro-pyridin-2-yl)-carbamic acid tert-butyl ester (CAS 1017782-13-6)
- Methyl 2-chloro-5-nitro-4-(propan-2-yloxy)benzoate (CAS 1143026-86-1)
- 2-(3-(6-Chloro-2H-chromen-3-yl)-1,2,4-oxadiazol-5-yl)acetonitrile (CAS 1269531-96-5)
- 3-chloro-4-(2-cyanophenoxy)benzoic acid (CAS 1281803-67-5)
- 3-(4-Chloro-2-cyanophenoxy)benzoic acid (CAS 1315368-61-6)
- 2-[(6-Chloro-3-nitropyridin-2-yl)amino]-3-methylbutanoic acid (CAS 1396963-89-5)
Recommended Standards
- 2-(4-Chlorophenoxy)isoindoline-1,3-dione (CAS 220464-84-6)
- 2-(5-Chlorobenzo[c]isoxazol-3-yl)benzoic acid (CAS 92414-55-6)
- 2-(2-Chloroacetamido)-4,5-dimethoxybenzoic acid (CAS 219527-54-5)
- 2-Chloro-5-formyl-4-((2-hydroxyphenyl)amino)nicotinonitrile (CAS 532412-96-7)
- 3-(2-Bromo-4-nitrophenoxy)azetidine (CAS 1340083-39-7)
- (3,5-Dichlorophenyl)(thiophen-2-yl)methanol (CAS 1250544-03-6)
- 2-(2,3-dihydro-1,4-benzoxathiin-2-yl)acetic acid (CAS 62591-01-9)
- N-(4-chloro-3-nitrophenyl)-2-((4-chlorophenyl)thio)acetamide (CAS 197512-96-2)
- Methyl 2-methanesulfonylpyrimidine-5-carboxylate (CAS 38275-49-9)
- 1-Amino-3-(m-tolyl)propan-2-ol (CAS 1225499-35-3)
- 5,6,7-Trimethoxy-1H-indole-2-carboxylic acid (CAS 128781-07-7)
- 2-(4-Oxoquinazolin-3(4H)-yl)ethyl 2-(4-chlorophenyl)acetate (CAS 107250-05-5)
- 2-[4-(Aminomethyl)phenyl]-6-methylbenzoxazole (CAS 875000-08-1)
- His-Aib-Semaglutide (CAS CATO-C4X-2226220)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com