8-Methoxychroman-2-one CAS 80515-75-9
| CAS No. | 80515-75-9 |
| Molecular Formula | C10H10O3 |
| Molecular Weight | 178.18 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
8-Methoxychroman-2-one (CAS 80515-75-9), molecular formula C10H10O3 and molecular weight 178.18 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 8-Methoxychroman-2-one (C10H10O3) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C10H10O3 |
| Molecular Weight | 178.18 g/mol |
| Appearance | Off-white to pale yellow crystalline powder |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
Related Methoxychroman Standards
- 3-Methoxychroman-4-one (CAS 82366-82-3)
- 5-Methoxychroman-2-one (CAS 82243-02-5)
- 5-Methoxychroman-4-one (CAS 863309-86-8)
- 6-Methoxychroman-4-one (CAS 5802-17-5)
- 7-Methoxychroman-2-one (CAS 20921-02-2)
- 7-Methoxychroman-4-one (CAS 42327-52-6)
- 8-Methoxychroman-4-one (CAS 20351-79-5)
- (R)-6-Methoxychroman-4-amine (CAS 1018978-89-6)
Recommended Standards
- 8-methoxy-3,4-dihydro-2H-1-benzopyran-3-one (CAS 91520-00-2)
- 8-Hydroxy-3,4-dihydrobenzo[b]oxepin-5(2H)-one (CAS 2226905-00-4)
- 8-Methoxyisochroman-1-one (CAS 30404-50-3)
- 7-Methyl-2,3-dihydrobenzo[b][1,4]dioxine-6-carbaldehyde (CAS 724791-20-2)
- (3-(2-Methoxypyridin-3-yl)phenyl)methanol (CAS 1349717-94-7)
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- Elagolix Impurity 95 (CAS CATO-C4X-206895)
- 1'H-Spiro[piperidine-4,3'-quinolin]-2'(4'H)-one (CAS 625829-51-8)
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- 2-(Chloromethyl)-1,1-dimethylcyclopropane (CAS 76200-12-9)
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