2-Trifluoromethanesulfonamidobenzoic acid CAS 80798-75-0
| CAS No. | 80798-75-0 |
| Molecular Formula | C8H6F3NO4S |
| Molecular Weight | 269.20 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
2-Trifluoromethanesulfonamidobenzoic acid (CAS 80798-75-0), molecular formula C8H6F3NO4S and molecular weight 269.20 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 2-Trifluoromethanesulfonamidobenzoic acid (C8H6F3NO4S) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C8H6F3NO4S |
| Molecular Weight | 269.20 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, ethanol, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Related Trifluoromethanesulfonamidobenzoic Standards
Recommended Standards
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- Methyl Chloride (ca. 5.7% in Tetrahydrofuran, ca. 1mol/L) (CAS 74-87-3)
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- 98035-79-1 Small cardioactive peptide A L-Methioninamide, L-alanyl-L-arginyl-L-prolylglycyl-L-tyrosyl-L-leucyl-L-alanyl-L-phenylalanyl-L-prolyl-L-arginyl- SCPA (CAS 98035-79-1)
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