Roxadustat Impurity N8 CAS 808116-62-3
| CAS No. | 808116-62-3 |
| Molecular Formula | C18H13BrN2O5 |
| Molecular Weight | 417.21 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 417.21 g/mol gives Roxadustat Impurity N8 distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
CATO supplies Roxadustat Impurity N8 (CAS 808116-62-3), a pharmacopoeial impurity reference standard (molecular formula C18H13BrN2O5, MW 417.21 g/mol) used for the identification and quantification of trace impurities in APIs.
Roxadustat Impurity N8 (C18H13BrN2O5) contains a flavonoid core, an amide group, a hydroxyl group, an ether linkage, bromine substitution. It is notably hygroscopic, halogen substitution raises its density and boiling point, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
CATO manufactures Roxadustat Impurity N8 under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C18H13BrN2O5 |
| Molecular Weight | 417.21 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Br-containing |
| Nitrogen Atoms | 2 |
Related Roxadustat Standards
- Roxadustat Impurity 145 (CAS CATO-C4X-2213145)
- Roxadustat impurity 120 (CAS CATO-C4X-2213120)
- Roxadustat impurity (CAS CATO-C4X-2213113)
- Roxadustat Impurity 19 (CAS CATO-C4X-221319)
- Roxadustat Impurity 97 (CAS CATO-C4X-221397)
- Roxadustat Impurity 54 (CAS CATO-C4X-221354)
- Roxadustat Impurity 28 (CAS CATO-C4X-221328)
- Roxadustat Impurity 102 (CAS CATO-C4X-2213102)
Recommended Standards
- Ethyl (3E)-3-{2-[2,4-dichloro-5-(2-methoxyethoxy)phenyl]hydrazin-1-ylidene}-4,4,4-trifluorobutanoate (CAS 866136-37-0)
- Tributyl(3,3-diethoxyprop-1-yn-1-yl)stannane (CAS 81535-78-6)
- 4-(5-(3,5-Dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methylbenzamide (CAS 864730-52-9)
- Tributylstannyl cyclohexanecarboxylate (CAS 2669-35-4)
- Spironolactone Impurity 15 (CAS CATO-C4X-134515)
- Ursodeoxycholic Acid impurity 80 (CAS CATO-C4X-142280)
- Olprinone Impurity 4 (CAS 106730-62-5)
- (2,4-Difluorophenyl)(pyrimidin-2-yl)methanamine (CAS 1341390-18-8)
- 1-(2-Nitro-5-(1,4-dioxa-8-azaspiro[4.5]Decan-8-yl)phenyl)ethan-1-one (CAS 923106-13-2)
- 1-(3,4-Difluorophenyl)-3-(4-methoxyphenyl)propan-1-one (CAS 898776-40-4)
- 2-((1-(2,5-Dichlorophenyl)ethyl)amino)ethan-1-ol (CAS 1038368-91-0)
- 2-((2-Methylbenzyl)amino)butan-1-ol (CAS 893583-73-8)
- Pirenzepine-d8 (CAS 1189944-02-2)
- 103244-41-3 Insulin-like Growth Factor-II fragment 33-40 Ser-Arg-Val-Ser-Arg-Arg-Ser-Arg (CAS 103244-41-3)
Why CATO?
- ISO 17034 accredited reference material producer (CNAS + ANAB dual accreditation)
- 130,000+ catalog items in stock, COA supplied with every batch
- Worldwide shipping with full export documentation (HS code guidance available)
- Technical support: +86 18665070610 / Nicole.chen@cato-chem.com