4-chloro-5H-imidazo[4,5-c]pyridine CAS 81053-66-9
| CAS No. | 81053-66-9 |
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 153.57 g/mol gives 4-chloro-5H-imidazo[4,5-c]pyridine distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-chloro-5H-imidazo[4,5-c]pyridine (CAS 81053-66-9), molecular formula C6H4ClN3 and molecular weight 153.57 g/mol, is a CATO reference standard with documented purity and traceability.
Based on its molecular formula C6H4ClN3, 4-chloro-5H-imidazo[4,5-c]pyridine contains a nitrile group, chlorine substitution, an aromatic ring system; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 153.57 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H4ClN3 |
| Molecular Weight | 153.57 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, faint amine-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related chloro Standards
- 5-Chloro-7H-pyrrolo[2,3-d]pyrimidine (CAS 1041864-02-1)
- 2-Chloro-1H-imidazo[4,5-b]pyridine (CAS 104685-82-7)
- 6-Chloro-[1,2,4]triazolo[4,3-a]pyridine (CAS 1048913-70-7)
- 3-chloro-[1,2,3]triazolo[1,5-a]pyridine (CAS 1087206-32-3)
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Recommended Standards
- 4-Chloro-3-hydroxybenzonitrile (CAS 51748-01-7)
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- 4-Chloro-5-methylpyrimidine-2-carbonitrile (CAS 955112-51-3)
- tert-Butyl methyl((1S,2S)-2-(methylamino)cyclopropyl)carbamate (CAS 2727885-13-2)
- Methyl 1-cyclopentylbenzimidazole-5-carboxylate (CAS 1355246-90-0)
- 8-Methoxy-6-nitro-3,4-dihydroquinolin-2(1H)-one (CAS 71280-12-1)
- 4-(Cyclopentyloxy)-3-fluoroaniline (CAS 1233860-12-2)
- Benzo[1,2-b:4,3-b′]dithiophene-4,5-dione (CAS 24243-31-0)
- 1,4-dimethylpyrrolidin-3-amine (CAS 1368129-80-9)
- 3-(2-(6-Amino-9H-purin-9-yl)ethyl)-2-(hydroxymethyl)thiazolidin-4-one (CAS 181507-39-1)
- Estradiol Valerate EP Impurity E (CAS 63042-28-4)
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