Clarithromycin EP Impurity E CAS 81103-14-2
| CAS No. | 81103-14-2 |
| Molecular Formula | C39H71NO13 |
| Molecular Weight | 761.98 g/mol |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
As a process- or degradation-related impurity, Clarithromycin EP Impurity E (CAS 81103-14-2, C39H71NO13) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Structurally, Clarithromycin EP Impurity E (C39H71NO13) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. The molecule exhibits a degree of unsaturation (DBE) of 5.0, corresponding to approximately 5 ring(s) or double-bond equivalent(s). With a molecular weight of 761.98 g/mol, it falls into the high-molecular-weight range. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
Physical & Chemical Properties
| Molecular Formula | C39H71NO13 |
| Molecular Weight | 761.98 g/mol |
| Purity | >95% |
| Storage | Store at room temperature, protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Nitrogen Atoms | 1 |
Related Clarithromycin Standards
- Clarithromycin EP Impurity F (CAS 128940-83-0)
- Clarithromycin EP Impurity P (CAS 123967-58-8)
- Clarithromycin Impurity 21 (CAS CATO-C4X-100221)
- Clarithromycin EP Impurity H (CAS 127140-69-6)
- Clarithromycin 9-Oxime (CAS 103450-87-9)
- Clarithromycin EP Impurity C (CAS 127253-06-9)
- Clarithromycin EP Impurity L (CAS 127253-05-8)
- Clarithromycin EP Impurity A (CAS 124412-58-4)
Recommended Standards
- N-formyl-175-J (CAS 1382419-20-6)
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- 3-((1-(1-(1H-Indol-3-yl)-2-phenylvinyl)naphthalen-2-yl)amino)-4-(((6-methoxyquinolin-4-yl)(5-vinylquinuclidin-2-yl)methyl)amino)cyclobut-3-ene-1,2-dione (CAS 2484838-16-4)
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- 3,5-Dichloro-4-isopropoxyphenol (CAS 1394927-31-1)
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- Methyl (2Z)-3-[(2H-1,3-benzodioxol-5-yl)amino]-2-[3-chloro-5-(trifluoromethyl)pyridin-2-yl]prop-2-enoate (CAS 477888-11-2)
- 1-Methylpyrrolidin-3-yl 4-aminobenzoate (CAS 802324-32-9)
- 3-Ethoxy-N-(4-ethoxybenzyl)aniline (CAS 1040685-47-9)
- Ethyl 2-((1R,3S)-3-((tert-butoxycarbonyl)amino)-1-hydroxy-4-methylpentyl)thiazole-4-carboxylate (CAS 944559-49-3)
- Tirzepatide Impurity 36 (CAS CATO-C4X-324036)
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