1'-Benzyl-6-chlorospiro[chroman-2,4'-piperidin]-4-one hydrochloride CAS 81109-67-3
| CAS No. | 81109-67-3 |
| Molecular Formula | C20H20ClNO2 |
| Molecular Weight | N/A |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
1'-Benzyl-6-chlorospiro[chroman-2,4'-piperidin]-4-one hydrochloride (CAS 81109-67-3), molecular formula C20H20ClNO2HCl and molecular weight 378.29 g/mol, is a CATO reference standard with documented purity and traceability.
1'-Benzyl-6-chlorospiro[chroman-2,4'-piperidin]-4-one hydrochloride (C20H20ClNO2HCl) contains a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. Halogen substitution raises its density and boiling point, its high carbon-to-hydrogen ratio confers good lipid solubility, the carboxyl group imparts weak acidity; these physicochemical properties determine the optimal preparation and storage of its standard solutions. The presence of an aromatic ring or conjugated system gives the compound characteristic absorption bands in the UV-Vis region, making it well suited to UV or diode-array detection (DAD).
As a certified reference material (CRM), 1'-Benzyl-6-chlorospiro[chroman-2,4'-piperidin]-4-one hydrochloride meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C20H20ClNO2 HCl |
| Molecular Weight | 378.29 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 10.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Benzyl Standards
- Benzyl 5-chlorospiro[indoline-3,4'-piperidine]-1'-carboxylate (CAS 1041704-16-8)
- 8-Chlorospiro[chroman-2,4'-piperidin]-4-one hydrochloride (CAS 1051383-40-4)
- 5-Chlorospiro[indoline-3,4'-piperidin]-2-one (CAS 1086063-33-3)
- 6-Chlorospiro[indoline-3,4'-piperidine] (CAS 1093956-70-7)
- 4'-Chlorospiro[cyclopentane-1,5'-pyrrolo[2,3-d]pyrimidin]-6'(7'H)-one (CAS 1226804-08-5)
- 5-Chlorospiro[chromane-2,4'-piperidine] hydrochloride (CAS 1241953-54-7)
- 5-Chlorospiro[2.5]oct-5-ene-6-carbaldehyde (CAS 1257050-19-3)
- 1'-Benzyl-8-chlorospiro[chroman-2,4'-piperidin]-4-one (CAS 1262757-25-4)
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- D-Gln19-Tirzepatide (CAS CATO-CPTD788915)
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