Adenosine Impurity 5 CAS 81162-88-1
| CAS No. | 81162-88-1 |
| Molecular Formula | C12H18N5O3S |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
Recommended for quantitative analysis by HPLC, GC, LC-MS/MS, or GC-MS as an external calibration standard; it can also be used for spiked-recovery experiments, LOD/LOQ determination, and LC-MS/MS multiple-reaction-monitoring (MRM) calibration.
As a process- or degradation-related impurity, Adenosine Impurity 5 (CAS 81162-88-1, C12H18N5O3SI) is essential for impurity profiling, related-substances testing, and forced-degradation studies in pharmaceutical development.
Based on its molecular formula C12H18N5O3SI, Adenosine Impurity 5 contains a nitrogen-containing heterocyclic scaffold, an amide group, a sulfone group, a hydroxyl group, an ether linkage, iodine substitution; these features give the compound characteristic absorption bands in UV spectroscopy. The molecular weight of 439.27 g/mol is directly relevant to the identification of the molecular ion in mass spectrometry. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
As a certified reference material (CRM), Adenosine Impurity 5 meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H18N5O3S I |
| Molecular Weight | 439.27 g/mol |
| Purity | >95% |
| Storage | Store in a cool place (≤25°C), protect from light, keep sealed and dry |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 6.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 5 |
| Sulfur Atoms | 1 |
Related Adenosine Standards
- 3ʹ-Adenosine phosphate 5ʹ-phosphate sulfate, tetralithium salt (CAS 102029-54-9)
- Adenosine 5-Monophosphoramidate Sodium Salt (CAS 102029-68-5)
- Adenosine 3',5'-cyclic Monophosphate Tris Salt (CAS 102029-77-6)
- Adenosine 5'-diphosphate bis(cyclohexylammonium) salt (CAS 102029-87-8)
- Adenosine 5′-triphosphate di(trihydroxymethylaminomethane) salt hydrate (CAS 102047-34-7)
- Adenosine-5-diphosphoglucose (CAS 102129-65-7)
- Adenosine 5′-(hexahydrogen pentaphosphate), P′′′′→5′-ester with thymidine (CAS 103137-88-8)
- Adenosine Impurity 27 (CAS 103828-77-9)
Recommended Standards
- Adefovir Impurity 12 (CAS 20245-85-6)
- Etizolam Impurity C19 (CAS 42753-80-0)
- Voclosporin Impurity 1 (CAS CATO-C4X-30651)
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- 12-Hydroxy-12-methyloctadecanoic acid (CAS 88099-77-8)
- 2-(3,6-Dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acetic acid (CAS 1071383-19-1)
- 7-Bromo-4-{[4-(trifluoromethyl)phenyl]methyl}-2,3,4,5-tetrahydro-1,4-benzoxazepin-3-one (CAS 1326888-60-1)
- tert-Butyl 4-((2-(2-aminopyrimidin-5-yl)-7-methyl-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)piperazine-1-carboxylate (CAS 1032756-20-9)
- 4-[(4-amino-3,5-dimethyl-1H-pyrazol-1-yl)methyl]benzoic acid,HCl (CAS 1431966-40-3)
- [D-Glu]3-Semaglutide (CAS CATO-C4X-2226253)
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