N'-(4-phenylthiazol-2-yl)benzohydrazide CAS 81556-13-0

Description

Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N'-(4-phenylthiazol-2-yl)benzohydrazide.

N'-(4-phenylthiazol-2-yl)benzohydrazide (CAS 81556-13-0), molecular formula C16H13N3OS and molecular weight 295.36 g/mol, is a CATO reference standard with documented purity and traceability.

The molecular framework of N'-(4-phenylthiazol-2-yl)benzohydrazide (C16H13N3OS) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, sulfur-containing functionality, a hydroxyl group, an ether linkage. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.

This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

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