Ethyl 4-amino-2-(4-chlorophenyl)pyrimidine-5-carboxylate CAS 823794-81-6
| CAS No. | 823794-81-6 |
| Molecular Formula | C13H12ClN3O2 |
| Molecular Weight | 277.71 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
CATO supplies Ethyl 4-amino-2-(4-chlorophenyl)pyrimidine-5-carboxylate (CAS 823794-81-6), a certified reference material (molecular formula C13H12ClN3O2, MW 277.71 g/mol) for analytical method development and quality control.
The molecular framework of Ethyl 4-amino-2-(4-chlorophenyl)pyrimidine-5-carboxylate (C13H12ClN3O2) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), Ethyl 4-amino-2-(4-chlorophenyl)pyrimidine-5-carboxylate meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C13H12ClN3O2 |
| Molecular Weight | 277.71 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep sealed and dry, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Hygroscopic; reseal immediately after opening; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 3 |
Related Ethyl Standards
- 2-Amino-N-(4-chloro-2-(1H-pyrrole-2-carbonyl)phenyl)acetamide (CAS 106410-13-3)
- N-(4-Amino-2-methoxyphenyl)-4-chloro-2-pyridinecarboxamide (CAS 1220031-44-6)
- Methyl 4-(amino(3-chloropyrazin-2-yl)methyl)benzoate (CAS 1620564-41-1)
- (3-Amino-6,7-dihydroisoxazolo[4,3-c]pyridin-5(4H)-yl)(4-chlorophenyl)methanone (CAS 61082-61-9)
- 4-Amino-2-chlorophenethyl pyrimidine-5-carboxylate (CAS 823793-63-1)
- 4-Amino-3-((4-chlorobenzyl)oxy)benzoic acid (CAS 1096330-77-6)
- 3-Amino-5-chloro-2-methoxyphenyl benzoate (CAS 1228182-63-5)
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Recommended Standards
- Betrixaban Impurity 4 (CAS 280773-17-3)
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- Benzyl ((4-chloropyrimidin-2-yl)methyl)carbamate (CAS 944906-72-3)
- N-(2-chloro-5-nitro-pyrimidin-4-yl)-6-oxa-3-azabicyclo[3.1.1]heptan-3-amine (CAS 2646592-57-4)
- Tert-butyl (5-hydroxy-7-oxaspiro[3.5]Nonan-2-yl)carbamate (CAS 2306269-00-9)
- 2-(3,4-Epoxycyclohexyl)ethyltrimethoxysilane (CAS 3388-04-3)
- 1-(3-Aminopyrrolidin-1-yl)-2-(4-methoxyphenyl)ethan-1-one hydrochloride (CAS 1591536-25-2)
- 2-(Dodecyloxy)benzonitrile (CAS 186029-18-5)
- 2-Methyl-1-(2,2,2-trifluoroethyl)piperazine (CAS 1250814-08-4)
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