3-(Phenylethynyl)cinnoline CAS 82453-35-8
| CAS No. | 82453-35-8 |
| Molecular Formula | C16H10N2 |
| Molecular Weight | 230.26 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
3-(Phenylethynyl)cinnoline (CAS 82453-35-8), molecular formula C16H10N2 and molecular weight 230.26 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 3-(Phenylethynyl)cinnoline (C16H10N2) is characterized by a nitrogen-containing heterocyclic scaffold, a nitrile group. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The high carbon-to-hydrogen ratio imparts good lipophilicity, allowing liquid-liquid extraction with non-polar solvents such as n-hexane or ethyl acetate.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C16H10N2 |
| Molecular Weight | 230.26 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 13.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Nitrogen Atoms | 2 |
Related Phenylethynyl Standards
- 4-(Phenylethynyl)cinnoline (CAS 18592-06-8)
- 1-Ethyl-4-(phenylethynyl)piperidin-4-ol (CAS 54848-20-3)
- 1-(Phenylethynyl)isoquinoline (CAS 70437-09-1)
- 3-(Phenylethynyl)isoquinoline (CAS 70437-12-6)
- 1-(Phenylethynyl)naphthalene (CAS 4044-57-9)
- 2-(Phenylethynyl)naphthalene (CAS 23975-17-9)
- 4′-(Phenylethynyl)acetophenone (CAS 1942-31-0)
- 1-(5-(Phenylethynyl)thiophen-2-yl)ethan-1-one (CAS 175203-54-0)
Recommended Standards
- 3-(Furan-2-yl)-N-(6-methylpyridin-2-yl)propanamide (CAS 827598-78-7)
- 3,3'-(Piperazine-1,4-diyl)dipropanoic acid (CAS 5649-49-0)
- 3-(Furan-2-yl)-3-(p-tolyl)propanoic acid (CAS 381199-78-6)
- 3,3',3''-Nitrilotris(propionamide) (CAS 2664-61-1)
- 2′-(Trifluoromethyl)acetophenone (CAS 17408-14-9)
- 5-(2-Chloroethyl)-1-methyl-1H-pyrazole hydrochloride (CAS 1797374-16-3)
- 3-Hydroxymyristic Acid (CAS 1961-72-4)
- 1-Phenyl-3-(pyridin-3-yl)prop-2-en-1-one (CAS 4452-13-5)
- Palmitic Acid-?13C16 (CAS 56599-85-0)
- [(E)-5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pent-4-enyl] 2,2-dimethylpropanoate (CAS 141091-32-9)
- 9-Methyl-2,8-diphenyl-1H-purin-6(9H)-one (CAS 61080-64-6)
- 1-Ethyl-3-(piperidin-1-yl)-1H-pyrazol-4-amine hydrochloride (CAS 1855889-27-8)
- 5,7-dimethylimidazo[1,2-a]pyrimidine-3-carbaldehyde (CAS 1354951-09-9)
- Tau Peptide (304-318) trifluoroacetate salt (CAS 330456-49-0)
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