4-Iodobenzenesulfonamide CAS 825-86-5
| CAS No. | 825-86-5 |
| Molecular Formula | C6H6INO2S |
| Molecular Weight | 283.09 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
4-Iodobenzenesulfonamide (CAS 825-86-5), molecular formula C6H6INO2S and molecular weight 283.09 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Iodobenzenesulfonamide (C6H6INO2S) is characterized by an amide group, a sulfone group, a carboxylic acid group, a hydroxyl group, an ether linkage, iodine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the protonation state of its nitrogen-containing groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C6H6INO2S |
| Molecular Weight | 283.09 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | I-containing |
| Nitrogen Atoms | 1 |
| Sulfur Atoms | 1 |
Recommended Standards
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- 2-Iodobenzene-1-sulfonamide (CAS 53730-99-7)
- Diethyl (2,5-dichlorophenyl)phosphonate (CAS 68373-17-1)
- Bis(1,1,1,3,3,3-hexafluoropropan-2-yl) sulfite (CAS 53517-89-8)
- 7-Aminopyrido[3,4-e][1,2,4]triazolo[1,5-a]pyrimidin-6(7H)-one (CAS 908553-83-3)
- 2,5-Bis(morpholinomethyl)-1,4-phenylene diacetate (CAS 1865-04-9)
- 1-Benzyl-5-oxo-2-(3-pyridinyl)-3-pyrrolidinecarboxylic acid (CAS 1822785-15-8)
- Quazepam (CAS 36735-22-5)
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- 4-((Cyclopentylamino)methyl)-N-(1-ethylpyrrolidin-3-yl)benzenesulfonamide (CAS 1336912-32-3)
- 1-(4-Methylphenyl)-4-phenyl-3-[(pyrrolidin-1-yl)methyl]azetidin-2-one (CAS 551921-49-4)
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- T-Peptide (CAS 2022956-62-1)
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