N-(3-Fluoro-4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine CAS 827031-17-4
| CAS No. | 827031-17-4 |
| Molecular Formula | C17H16FN3O |
| Molecular Weight | 297.33 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Under current pharmacopoeial and regulatory frameworks, quality-control requirements for this class of reference material explicitly involve the control of targets including N-(3-Fluoro-4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine.
N-(3-Fluoro-4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine (CAS 827031-17-4), molecular formula C17H16FN3O and molecular weight 297.33 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of N-(3-Fluoro-4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine (C17H16FN3O) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, fluorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. The aromatic system may exhibit native fluorescence, enabling detection with a fluorescence detector (FLD).
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Physical & Chemical Properties
| Molecular Formula | C17H16FN3O |
| Molecular Weight | 297.33 g/mol |
| Appearance | Pale yellow to yellow crystalline powder. (slight halide-like odor) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 11.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1986 |
| Halogen Content | F-containing |
| Nitrogen Atoms | 3 |
Related N Standards
- 1-(3-Fluoro-4-methylphenyl)-3-(1-methyl-1H-indol-3-yl)urea (CAS 941879-45-4)
- N-(2-Fluoro-4-methoxyphenyl)-N,2-dimethylquinazolin-4-amine (CAS 827031-33-4)
- Methyl 5-(2-fluoro-5-methoxyphenyl)-4-(hydroxymethyl)-2-methylpyrrolidine-2-carboxylate (CAS 1217831-96-3)
- Ethyl 5-fluoro-3-(p-tolyl)-1H-indole-2-carboxylate (CAS 1363405-15-5)
- 6-Fluoro-2-(4-methoxybenzyl)-7-methylisoquinolin-1(2H)-one (CAS 923023-39-6)
- Benzyl 3-fluoro-4,4-dimethoxypiperidine-1-carboxylate (CAS 355006-62-1)
- 2-Fluoro-N-(2-(6-oxopyridazin-1(6H)-yl)ethyl)benzenesulfonamide (CAS 1021219-23-7)
- 2-((3-Fluoro-4-methoxyphenyl)amino)pyridine-3-sulfonamide (CAS 1340753-74-3)
Recommended Standards
- N-(2-Hydroxyethyl)-3-(3-methyl-5-oxo-4,5-dihydro-1H-pyrazol-1-yl)benzenesulfonamide (CAS 68003-42-9)
- N-(5,6-dihydrofuro[2,3-h]quinazolin-2-yl)thiophene-2-carboxamide (CAS 400083-45-6)
- N-(benzo[d]oxazol-6-ylcarbamothioyl)benzamide (CAS 861208-80-2)
- N-(1,1-Dioxido-2,3-dihydrothiophen-3-yl)-2-(4-methoxyphenoxy)acetamide (CAS 696610-18-1)
- 4-(chloromethyl)-3-fluoro-pyridine (CAS 1060802-36-9)
- (2R,4S)-4-hydroxypiperidine-2-carboxylic acid (CAS 126641-65-4)
- Ethyl 5-ethoxyoxazole-4-carboxylate (CAS 14423-15-5)
- 2-[(2R,5S)-5-(Methanesulfonylamino-methyl)-pyrrolidin-2-yl]-N-methyl-acetamide (CAS 1442080-84-3)
- 3-(3-Fluoro-4-methoxyphenyl)-1,2,4-thiadiazol-5-amine (CAS 1482000-91-8)
- 2-(tert-Butoxy)-2-phenylacetic acid (CAS 66667-02-5)
- Ethyl 6-(2,6-dimethoxyphenyl)-6-oxohexanoate (CAS 898758-47-9)
- Basic Orange 14 (CAS 10127-02-3)
- Cefradine Impurity 19 (CAS CATO-C4X-121519)
- (Ser(PO?H?)2?2)-Tau Peptide (260-264) PAb Blocking trifluoroacetate salt (CAS 2022956-57-4)
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