4-(Trifluoromethoxy)phenol CAS 828-27-3
| CAS No. | 828-27-3 |
| Molecular Formula | C7H5F3O2 |
| Molecular Weight | 178.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
Compared with other compounds in its class, the molecular weight of 178.11 g/mol gives 4-(Trifluoromethoxy)phenol distinctive chromatographic separation conditions and mass-spectrometry parameter settings.
4-(Trifluoromethoxy)phenol (CAS 828-27-3), molecular formula C7H5F3O2 and molecular weight 178.11 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-(Trifluoromethoxy)phenol (C7H5F3O2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
Recommended for analytical method development and validation; each product is supplied with a full Certificate of Analysis (COA) ensuring ISO 17034 metrological traceability.
CATO manufactures 4-(Trifluoromethoxy)phenol under ISO 17034:2016 accreditation with dual CNAS and ANAB accreditation. Each batch is characterized by orthogonal methods and supplied with a full Certificate of Analysis (COA), ensuring metrological traceability.
Physical & Chemical Properties
| Molecular Formula | C7H5F3O2 |
| Molecular Weight | 178.11 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 4.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1957 |
| Halogen Content | F-containing |
Related Trifluoromethoxy Standards
- 2-(Trifluoromethoxy)pyridin-3-amine (CAS 1221171-94-3)
- 2-(Trifluoromethoxy)pyridin-4-amine (CAS 1221172-01-5)
- 6-(Trifluoromethoxy)pyridin-3-amine (CAS 135900-33-3)
- 5-(Trifluoromethoxy)pyridin-3-amine (CAS 1361856-17-8)
- 3-(Trifluoromethoxy)phenol (CAS 827-99-6)
- 3-(Trifluoromethoxy)pyridin-4-amine (CAS 827586-90-3)
- 5-(Trifluoromethoxy)pyridin-2(1H)-one (CAS 1052722-33-4)
- 6-(Trifluoromethoxy)pyrazin-2-amine (CAS 1261576-51-5)
Recommended Standards
- 4-(Difluoromethoxy)-5-fluoropyridin-2-amine (CAS 2231676-95-0)
- 4-(Trifluoromethyl)benzene-1,2-diol (CAS 37519-09-8)
- 4-(Difluoromethoxy)-3-fluoropyridin-2-amine (CAS 2231674-72-7)
- 4,6-Diazido-1,3,5-triazin-2-amine (CAS 7123-41-3)
- 1-Phenyl-6-oxabicyclo[3.1.0]hexane (CAS 10294-00-5)
- 2-(4-Benzhydrylpiperazin-1-yl)-1-(4-chlorophenyl)ethan-1-ol (CAS 156810-00-3)
- 6-Amino-4-(difluoromethyl)nicotinic acid (CAS 1805274-11-6)
- Ethyl 11(Z),14(Z),17(Z)-eicosatrienoate (CAS 99660-95-4)
- Tert-butyl(2r)-2-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2h-pyridine-1-carboxylate (CAS 2304631-54-5)
- Rebamipide Impurity 61 (CAS CATO-C4X-152361)
- Ethyl 3-azido-2,2-difluoropropanoate (CAS 1403948-00-4)
- 6-Chloro-4-phenyl-2(1H)-quinazolinone (CAS 4797-43-7)
- N-(2-Chloro-5-methoxypyrimidin-4-yl)-1H-indazol-6-amine (CAS 1447607-39-7)
- Allo-Thr5-Tirzepatide (CAS CATO-CPTD788934)
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