4-Fluoro-3-methoxybenzoyl chloride CAS 82846-19-3
| CAS No. | 82846-19-3 |
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
4-Fluoro-3-methoxybenzoyl chloride (CAS 82846-19-3), molecular formula C8H6ClFO2 and molecular weight 188.58 g/mol, is a CATO reference standard with documented purity and traceability.
The molecular framework of 4-Fluoro-3-methoxybenzoyl chloride (C8H6ClFO2) is characterized by a carboxylic acid group, a hydroxyl group, an ether linkage, fluorine/chlorine substitution, an aromatic ring system. In reversed-phase chromatography, its retention is governed primarily by the polarity and ionization state of its functional groups, which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Halogen substitution (F/Cl/Br/I) produces a distinctive isotope pattern in mass spectrometry, a valuable aid for qualitative confirmation.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
Physical & Chemical Properties
| Molecular Formula | C8H6ClFO2 |
| Molecular Weight | 188.58 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor, low volatility) |
| Purity | 97%+ |
| Storage | Store at 2-8°C, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in methanol, acetonitrile, DMSO, water (slightly soluble) |
| Stability | May oxidize slowly on prolonged air exposure; Contains ester bond; hydrolyzes under strong alkaline conditions |
| Degree of Unsaturation (DBE) | 5.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | F/Cl-containing |
Related Fluoro Standards
- 4-Fluoro-3-methylphenyl Chloroformate (CAS 1001095-14-2)
- 3-Fluoro-2-methoxybenzoyl chloride (CAS 106428-06-2)
- 3-Fluoro-5-methoxybenzoyl chloride (CAS 1092789-19-9)
- 4-Fluoro-3-(chloromethyl)benzoic acid (CAS 1378830-30-8)
- 4-Fluoro-2-methylphenyl Chloroformate (CAS 1552201-86-1)
- 2-Fluoro-3-methoxybenzoyl chloride (CAS 850563-45-0)
- 2-Fluoro-4-methoxybenzoyl Chloride (CAS 321-24-4)
- 2-Fluoro-5-methoxybenzoyl chloride (CAS 659737-56-1)
Recommended Standards
- 4-Fluoro-2-methoxybenzoyl chloride (CAS 51671-69-3)
- 5-Chloro-2-fluoro-4-methoxybenzaldehyde (CAS 221622-80-6)
- 4-Chloro-3-fluorophenylacetic Acid (CAS 883500-51-4)
- 5-Chloro-2-fluorophenylacetic Acid (CAS 261762-97-4)
- 1-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-4,4,4-trifluorobutane-1,3-dione (CAS 832739-46-5)
- ethyl 6-(chloromethyl)-4-(4-chlorophenyl)-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate (CAS 475042-34-3)
- 2-[(2,5-dimethylphenyl)sulfanyl]acetonitrile (CAS 103575-52-6)
- 4,6-Dichloro-5-iodopyrimidin-2-amine (CAS 1208108-99-9)
- 6-(Aminomethyl)-3-methoxypicolinonitrile (CAS 1956379-91-1)
- 5-Bromo-3-nitro-2-(trifluoromethyl)pyridine (CAS 1211540-75-8)
- 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, sulfate (CAS 23654-78-6)
- 2-Chloro-4-methoxybenzene-1-sulfonyl chloride (CAS 23094-94-2)
- 6-Chloro-5-nitroisatin (CAS 177944-72-8)
- MLCK inhibitor peptide 18 (CAS 224579-74-2)
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