Atomoxetine Impurity 1 CAS 82857-40-7
| CAS No. | 82857-40-7 |
| Molecular Formula | C17H21NO |
| Molecular Weight | N/A |
| Category | Pharmacopoeial Impurity Standards / EP Impurities |
| Availability | In Stock |
Chemical Structure
Description
The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.
Atomoxetine Impurity 1 (CAS 82857-40-7) is a certified pharmaceutical impurity reference standard with the molecular formula C17H21NOHCl and a molecular weight of 291.82 g/mol.
The molecular framework of Atomoxetine Impurity 1 (C17H21NOHCl) is characterized by a steroid core, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.
Physical & Chemical Properties
| Molecular Formula | C17H21NO HCl |
| Molecular Weight | 291.82 g/mol |
| Appearance | Off-white to pale yellow crystalline powder. (slight halide-like odor) |
| Purity | >95% |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in chloroform, dichloromethane, ethyl acetate, DMSO |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 7.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 1 |
Related Atomoxetine Standards
- Atomoxetine Impurity 50 (CAS 1007832-68-9)
- Atomoxetine impurity 40 (CAS 1010818-92-4)
- Atomoxetine impurity 41 (CAS 1010818-92-4（free base）)
- Atomoxetine EP Impurity C (CAS 1010818-96-8)
- Atomoxetine Impurity 9 HCl (CAS 1011-59-2)
- Atomoxetine EP impurity B (CAS 105314-53-2)
- Atomoxetine impurity 01 (CAS 109306-10-7)
- Atomoxetine EP Impurity H (S-Isomer) (CAS 114133-37-8)
Recommended Standards
- Isepamicin Impurity 7 (CAS CATO-C4X-31117)
- Miglitol Impurity 19 (CAS 78614-47-8)
- Flurbiprofen Impurity 164 (CAS 52806-83-4)
- (Z)-{2-[(2,4-dichlorophenyl)carbamoyl]ethylidene}amino N-phenylcarbamate (CAS 477851-55-1)
- 2-(1-Benzyl-1H-imidazol-4-yl)ethan-1-amine dihydrochloride (CAS 51720-40-2)
- 1-(2-Nitrophenyl)-1H-purin-6(7H)-one (CAS 144106-37-6)
- Methyl 2-(1-(pyridin-3-ylmethyl)piperidin-4-yl)acetate (CAS 946699-25-8)
- N-(4-Nitrobenzyl)cyclohexanamine hydrobromide (CAS 1609409-25-7)
- Cefotaxime Impurity 10 (CAS CATO-C4X-120110)
- (Glu1)-Fibrinopeptide B (human) (CAS 103213-49-6)
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