Metamizole EP Impurity B (Ampyrone) CAS 83-07-8

Purity >95%In StockPharmacopoeial Impurity Standards
CAS No.83-07-8
Molecular FormulaC11H13N3O
Molecular Weight203.24 g/mol
CategoryPharmacopoeial Impurity Standards / EP Impurities
AvailabilityIn Stock

Chemical Structure

Metamizole EP Impurity B (Ampyrone) CAS 83-07-8 chemical structure

Description

Metamizole EP Impurity B (Ampyrone) (CAS 83-07-8) is a certified pharmaceutical impurity reference standard with the molecular formula C11H13N3O and a molecular weight of 203.24 g/mol.

Metamizole EP Impurity B (Ampyrone) (C11H13N3O) contains a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage. Its high carbon-to-hydrogen ratio confers good lipid solubility; these physicochemical properties determine the optimal preparation and storage of its standard solutions. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.

This reference standard supports related-substances testing and method development in line with ICH Q3A/Q3B guidance on impurity control, and is suitable for system suitability testing and forced-degradation studies.

The assigned purity is verified by mass-balance and quantitative NMR (qNMR) approaches, with the expanded uncertainty reported at a 95% confidence level (k=2). Batch homogeneity and stability are independently assessed for every lot.

Physical & Chemical Properties

Molecular FormulaC11H13N3O
Molecular Weight203.24 g/mol
Purity>95%
StorageStore at 2-8°C, protect from light
Solubility (reference)Soluble in DMSO, DMF, methanol
StabilityLight-sensitive; avoid direct strong light
Degree of Unsaturation (DBE)7.0
UV AbsorptionUV-absorbing
Structural FeaturesAromatic ring present
CAS Registry Year (est.)1957
Nitrogen Atoms3

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