1-(2,4-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone CAS 83227-43-4
| CAS No. | 83227-43-4 |
| Molecular Formula | C12H8Cl2N2O |
| Molecular Weight | 267.11 g/mol |
| Category | Pharmaceutical Standards / API Standards |
| Availability | In Stock |
Chemical Structure
Description
The molecular framework of 1-(2,4-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone (C12H8Cl2N2O) is characterized by a nitrogen-containing heterocyclic scaffold, an amide group, a hydroxyl group, an ether linkage, chlorine substitution. In reversed-phase chromatography, its retention is governed primarily by its high hydrophobicity (logP), which provides a practical basis for HPLC-UV/DAD or LC-MS method development. Nitrogen-containing functional groups confer excellent ionization efficiency in positive-ion electrospray (ESI) mode, making the compound well suited to LC-MS/MS analysis.
CATO supplies 1-(2,4-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone (CAS 83227-43-4), a certified reference material (molecular formula C12H8Cl2N2O, MW 267.11 g/mol) for analytical method development and quality control.
This reference standard is suitable for quantitative analysis on major chromatographic platforms including HPLC, GC, LC-MS/MS, and GC-MS, serving as an external calibration standard or a system suitability test reference material.
As a certified reference material (CRM), 1-(2,4-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone meets the metrological traceability requirements of ISO/IEC 17025 laboratories. Batch-to-batch consistency is monitored via control charts to guarantee comparable assigned values across lots.
Physical & Chemical Properties
| Molecular Formula | C12H8Cl2N2O |
| Molecular Weight | 267.11 g/mol |
| Purity | 97%+ |
| Storage | Store at 2-8°C, protect from light, keep tightly closed to prevent evaporation |
| Solubility (reference) | Soluble in DMSO, DMF, methanol |
| Stability | May oxidize slowly on prolonged air exposure; Light-sensitive; avoid direct strong light |
| Degree of Unsaturation (DBE) | 9.0 |
| UV Absorption | UV-absorbing |
| Structural Features | Aromatic ring present |
| CAS Registry Year (est.) | 1980 |
| Halogen Content | Cl-containing |
| Nitrogen Atoms | 2 |
Related Dichlorophenyl Standards
- 5-(3,5-Dichlorophenyl)-2-formylphenol (CAS 1262003-94-0)
- (2E)-1-(2,5-Dichlorophenyl)-3-(furan-2-yl)prop-2-en-1-one (CAS 1335135-74-4)
- 5-(3,5-Dichlorophenyl)nicotinamide (CAS 1346691-99-3)
- (2E)-1-(2,4-Dichlorophenyl)-3-(furan-2-yl)prop-2-en-1-one (CAS 918151-23-2)
- (2E)-1-(3,4-Dichlorophenyl)-3-(furan-2-yl)prop-2-en-1-one (CAS 209600-08-8)
- 1-(2,5-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone (CAS 88283-32-3)
- 1-(3,4-Dichlorophenyl)-2-(pyrazin-2-yl)ethanone (CAS 88283-35-6)
- 2-(3-(2,6-Dichlorophenyl)-5-methylisoxazol-4-yl)acetonitrile (CAS 519056-44-1)
Recommended Standards
- (3,5-Dichloro-2-hydroxyphenyl)(phenyl)methanone (CAS 7396-92-1)
- 1-(4-Chlorophenyl)-2-(2-chloropyrimidin-4-yl)ethanone (CAS 646527-94-8)
- 2,4-Dichloro-N-(pyridin-3-yl)benzamide (CAS 197800-84-3)
- 2-((5,7-Dichloro-2-methylquinolin-8-yl)oxy)acetonitrile (CAS 88757-24-8)
- 2-(3,4-Dichlorophenyl)-2-fluoroacetic acid (CAS 29229-91-2)
- (1s,3s)-3-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)-1-methylcyclobutan-1-ol (CAS 936901-75-6)
- 3-Methyl-[2,3'-bipyridine]-5'-carbaldehyde (CAS 1346686-63-2)
- 7-Bromo-1H-pyrido[2,3-b][1,4]oxazin-2(3H)-one (CAS 105544-36-3)
- 4-Methyl-2-((pyridin-2-ylmethyl)amino)pentan-1-ol (CAS 1235804-36-0)
- N-[(1R,2R)-2-(Dimethylamino)-1,2-diphenylethyl]-N'-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosyl)thiourea (CAS 1440198-44-6)
- N-(furan-2-ylmethyl)-N-(1-(o-tolylcarbamoyl)cyclohexyl)nicotinamide (CAS 503561-70-4)
- 2-(3-(Methoxymethyl)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (CAS 675605-91-1)
- (1e)-1-(2-hydroxyphenyl)-4,4-dimethylpent-1-en-3-one (CAS 55210-65-6)
- Semaglutide impurity 27 (CAS CATO-C4X-222627)
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